Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.710203
Keywords
epigenetic; chromodomain helicase DNA-binding protein; chromatin remodeling; histone modification; CHARGE syndrome
Categories
Funding
- National Natural Science Foundation of China (NSFC) [81701009, 82001017]
- West China Hospital of Stomatology [RCDWJS2020-23]
- China Postdoctoral Science Foundation Grant [2019TQ0218, 2020M683328]
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CHD proteins play a crucial role in stem cell differentiation and human diseases.
Background: Regulation of gene expression is critical for stem cell differentiation, tissue development, and human health maintenance. Recently, epigenetic modifications of histone and chromatin remodeling have been verified as key controllers of gene expression and human diseases. Objective: In this study, we review the role of chromodomain helicase DNA-binding (CHD) proteins in stem cell differentiation, cell fate decision, and several known human developmental disorders and cancers. Conclusion: CHD proteins play a crucial role in stem cell differentiation and human diseases.
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