Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.742662
Keywords
sepsis; cardiomyocyte apoptosis; IL-13; ILC2; stat3
Categories
Funding
- National Natural Science Foundation of China [82072199, 82172168]
- Clinical Research Plan of Shanghai Hospital Development Center [SHDC2020CR3084B]
- Shanghai Collaborative Innovation Center for Translational Medicine Fund [TM202013]
- Translational Medicine Cross Research Fund of Shanghai Jiao Tong University [ZH2018ZDB01, YG2021QN124, YG2021ZD27]
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IL-13 has been found to have anti-apoptotic effects during sepsis, aiding in the recovery of heart function. This protective effect is likely achieved through enhancing the phosphorylation of STAT3 Ser727 and is associated with ILC2. These findings offer a promising potential treatment for sepsis-induced cardiomyopathy.
The involvement of cardiomyopathy during sepsis means higher mortality and prolonged length of hospital stay. Many efforts have been made to alleviate the apoptosis of cardiomyocytes in sepsis. The huge potential of IL-13 in tissue repair has attracted increasing attention. In the present study, we used LPS-treated mice or primary cardiomyocytes as a sepsis model to explore the anti-apoptotic ability of IL-13. It was found that an increased level of exogenous IL-13 was beneficial to the recovery of heart function in sepsis, and this anti-apoptotic effect of IL-13 was probably through enhancing the phosphorylation of STAT3 Ser727. In addition, we identified that the heart protective effect of IL-13 was associated with type 2 innate lymphocytes (ILC2). All these findings may provide a potential promising treatment for sepsis-induced cardiomyopathy.
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