4.7 Review

Targeting Ferroptosis to Treat Cardiovascular Diseases: A New Continent to Be Explored

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Corticostriatal dysfunction and social interaction deficits in mice lacking the cystine/glutamate antiporter

Eduard Bentea et al.

Summary: The study revealed that the lack of the specific subunit xCT of the system x(c)(-) in xCT(-/-) mice leads to decreased corticostriatal neurotransmission, possibly due to reduced extracellular glutamate availability rather than morphological or structural abnormalities. Additionally, the xCT(-/-) mice exhibited decreased intracellular glutamate density, aberrant presynaptic protein expression, and altered kinase network signaling in the striatum, potentially contributing to changes in postsynaptic responses and behavioral phenotypes indicative of autism spectrum disorder.

MOLECULAR PSYCHIATRY (2021)

Article Cell Biology

Human umbilical cord blood-derived MSCs exosome attenuate myocardial injury by inhibiting ferroptosis in acute myocardial infarction mice

Yufang Song et al.

Summary: This study found that exosomes derived from human umbilical cord blood-derived MSCs (HUCB-MSC) inhibit ferroptosis by regulating DMT1 expression through miR-23a-3p, reducing myocardial injury.

CELL BIOLOGY AND TOXICOLOGY (2021)

Article Pharmacology & Pharmacy

Ferroptosis occurs in phase of reperfusion but not ischemia in rat heart following ischemia or ischemia/reperfusion

Li-Jing Tang et al.

Summary: The study evaluated the contribution of ferroptosis to myocardial ischemia or reperfusion injury, finding that ferroptosis mainly occurs during myocardial reperfusion. The use of iron chelator deferoxamine attenuated reperfusion injury but had no significant effect on ischemic injury.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

Article Immunology

ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation

Yu Cui et al.

Summary: ACSL4 is an important regulator of neuronal death and neuroinflammation in ischemic stroke, with its suppression protecting mice against brain ischemia and promoting neuronal death via enhancing lipid peroxidation. Additionally, knockdown of ACSL4 can inhibit proinflammatory cytokine production in microglia.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Cardiac & Cardiovascular Systems

Oxidized phosphatidylcholines trigger ferroptosis in cardiomyocytes during ischemia-reperfusion injury

Aleksandra Stamenkovic et al.

Summary: Oxidized phosphatidylcholines (OxPC) generated during reperfusion injury induce cardiomyocyte death through ferroptosis, which can be attenuated by neutralization of OxPC or with ferrostatin-1. Understanding this pathway may lead to novel strategies for preventing cell death during myocardial reperfusion injury.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2021)

Article Cell Biology

Astragaloside IV inhibits adriamycin-induced cardiac ferroptosis by enhancing Nrf2 signaling

Li-Fei Luo et al.

Summary: The study demonstrated that Astragaloside IV (AsIV) protected rats against adriamycin (ADR)-induced cardiomyopathy by suppressing oxidative stress and enhancing Nrf2 signaling pathway, indicating its potential as a protective agent in myocardial fibrosis induced by ADR.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2021)

Article Biochemistry & Molecular Biology

ELAVL1 is transcriptionally activated by FOXC1 and promotes ferroptosis in myocardial ischemia/reperfusion injury by regulating autophagy

Hui-Yong Chen et al.

Summary: Myocardial ischemia is a common cardiovascular disease that can lead to significant morbidity and mortality. This study aimed to investigate the role of ELAVL1 in regulating myocardial ischemia and reperfusion injury, and found that ELAVL1 may promote ferroptosis through modulating autophagy, leading to myocardial injury. Inhibition of ELAVL1-mediated autophagic ferroptosis could be a potential new treatment strategy for myocardial I/R injury.

MOLECULAR MEDICINE (2021)

Article Cell Biology

The Protective Effect of Cyanidin-3-Glucoside on Myocardial Ischemia-Reperfusion Injury through Ferroptosis

Xin Shan et al.

Summary: The study demonstrated that C3G has a protective effect against myocardial ischemia-reperfusion injury by inhibiting oxidative stress and ferroptosis-related protein expression, thus highlighting its potential as a protective agent for myocardium.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Article Clinical Neurology

Myocardial Iron Overload in an Experimental Model of Sudden Unexpected Death in Epilepsy

Enes Akyuz et al.

Summary: Uncontrolled repetitive generalized tonic-clonic seizures are the main risk factor for sudden unexpected death in epilepsy. These seizures can induce cardiac dysfunction and lead to terminal cardiac arrhythmia, potentially contributing to SUDEP, through mechanisms involving hypoxic stress, neural-cardiac injury, and accumulation of hemosiderin in the heart. Therapeutic strategies targeting cardiac iron overload may reduce the risk of SUDEP in patients with refractory epilepsy.

FRONTIERS IN NEUROLOGY (2021)

Review Pharmacology & Pharmacy

Ferroptosis and its emerging roles in cardiovascular diseases

Ning Li et al.

Summary: Ferroptosis, a novel form of regulated cell death driven by iron-dependent lipid peroxidation, has been found to play a role in various cardiovascular diseases, but the specific mechanisms by which it contributes to the progression of cardiovascular diseases remain unclear.

PHARMACOLOGICAL RESEARCH (2021)

Article Pharmacology & Pharmacy

Baicalin Prevents Myocardial Ischemia/Reperfusion Injury Through Inhibiting ACSL4 Mediated Ferroptosis

Zhenyu Fan et al.

Summary: Baicalin, a natural flavonoid glycoside, protects against myocardial ischemia/reperfusion injury by suppressing ACSL4-controlled ferroptosis. This study provides a novel target for the prevention of myocardial ischemia/reperfusion injury.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

Ferroptosis Is a Potential Novel Diagnostic and Therapeutic Target for Patients With Cardiomyopathy

Zhenyu Zhai et al.

Summary: Ferroptosis, a recently discovered iron-dependent programmed cell death pathway, plays a significant role in cardiovascular diseases. Research has shown that blocking the ferroptosis pathways can alleviate myocardial injury. Therefore, ferroptosis may be a novel diagnostic and therapeutic target for patients suffering from cardiomyopathy in the future.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Article Cardiac & Cardiovascular Systems

circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p

Haoyuan Zheng et al.

Summary: This study investigated the regulatory mechanism of circRNA and iron metabolism in heart failure, identifying genes related to iron metabolism and constructing a circRNA-miRNA-mRNA regulatory network. Experimental validations in heart failure mice confirmed the predicted effects on FTH1 expression, as well as the presence of fibrosis and elevated levels of iron and MDA in myocardial tissues. The findings suggest potential circRNA targets for heart failure treatment.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Critical Care Medicine

Etomidate Attenuates the Ferroptosis in Myocardial Ischemia/Reperfusion Rat Model via Nrf2/HO-1 Pathway

Zhenqian Lv et al.

Summary: Etomidate (Eto) attenuated myocardial ischemia reperfusion injury (MIRI) by inhibiting ferroptosis via the Nrf2 pathway, demonstrating anti-inflammatory and anti-fibrotic effects in MIRI rats.

SHOCK (2021)

Article Biochemistry & Molecular Biology

Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion

Li-Jing Tang et al.

Summary: Iron overload induces ferroptosis in the heart post ischemia/reperfusion (I/R), with the USP7/p53/TfR1 pathway identified as promoting the ferroptosis. Inhibition of USP7 reduces ferroptosis and myocardial I/R injury by activating the p53/TfR1 pathway.

FREE RADICAL BIOLOGY AND MEDICINE (2021)

Review Medicine, Research & Experimental

Ferroptosis as a novel therapeutic target for cardiovascular disease

Xiaoguang Wu et al.

Summary: Cell death is a significant factor in cardiovascular disease pathophysiology. Ferroptosis, a regulated cell death form characterized by iron overload and lipid hydroperoxide accumulation, is closely associated with various diseases and plays critical roles in cardiomyopathy, myocardial infarction, ischemia/reperfusion injury, and heart failure. Targeting ferroptosis may offer potential novel therapeutic strategies for cardiovascular diseases.

THERANOSTICS (2021)

Article Cardiac & Cardiovascular Systems

Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells

Ariunaa Sampilvanjil et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2020)

Article Biochemistry & Molecular Biology

Ferroptosis Is Involved in Diabetes Myocardial Ischemia/Reperfusion Injury Through Endoplasmic Reticulum Stress

Wenyuan Li et al.

DNA AND CELL BIOLOGY (2020)

Article Oncology

The effect of deferasirox on endocrine complications in children with thalassemia

Burcak Kurucu Bilgin et al.

PEDIATRIC HEMATOLOGY AND ONCOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Action of iron chelator on intramyocardial hemorrhage and cardiac remodeling following acute myocardial infarction

Bita Behrouzi et al.

BASIC RESEARCH IN CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Loss of Cardiac Ferritin H Facilitates Cardiomyopathy via Slc7a11-Mediated Ferroptosis

Xuexian Fang et al.

CIRCULATION RESEARCH (2020)

Article Medicine, Research & Experimental

Mitochondria-dependent ferroptosis plays a pivotal role in doxorubicin cardiotoxicity

Tomonori Tadokoro et al.

JCI INSIGHT (2020)

Review Biochemistry & Molecular Biology

The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection

Tanya Ravingerova et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Pharmacology & Pharmacy

The Application of Ferroptosis in Diseases

Yangmin Qiu et al.

PHARMACOLOGICAL RESEARCH (2020)

Review Cardiac & Cardiovascular Systems

Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019 Update From the GBD 2019 Study

Gregory A. Roth et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2020)

Article Biochemistry & Molecular Biology

Ferritinophagy-mediated ferroptosis is involved in sepsis-induced cardiac injury

Ning Li et al.

FREE RADICAL BIOLOGY AND MEDICINE (2020)

Article Cardiac & Cardiovascular Systems

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary

Donna K. Arnett et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Multidisciplinary Sciences

Ferroptosis as a target for protection against cardiomyopathy

Xuexian Fang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

Editorial Material Cardiac & Cardiovascular Systems

Acute Decompensated Heart Failure Complicated by Respiratory Failure

P. Elliott Miller et al.

CIRCULATION-HEART FAILURE (2019)

Review Cell Biology

Iron and the heart: A paradigm shift from systemic to cardiomyocyte abnormalities

Aleksandra Paterek et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Medicine, Research & Experimental

Ferroptotic cell death and TLR4/Trif signaling initiate neutrophil recruitment after heart transplantation

Wenjun Li et al.

JOURNAL OF CLINICAL INVESTIGATION (2019)

Editorial Material Cell Biology

Interferon-γ induces cancer cell ferroptosis

Laurence Zitvogel et al.

CELL RESEARCH (2019)

Article Environmental Sciences

PM2.5 induces ferroptosis in human endothelial cells through iron overload and redox imbalance

Yan Wang et al.

ENVIRONMENTAL POLLUTION (2019)

Article Biochemistry & Molecular Biology

Role of TLR4/NADPH oxidase 4 pathway in promoting cell death through autophagy and ferroptosis during heart failure

Xiaoqing Chen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Biochemistry & Molecular Biology

Iron homeostasis and iron-regulated ROS in cell death, senescence and human diseases

Toshitaka Nakamura et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2019)

Review Physiology

FUNDAMENTAL MECHANISMS OF REGULATED CELL DEATH AND IMPLICATIONS FOR HEART DISEASE

Dominic P. Del Re et al.

PHYSIOLOGICAL REVIEWS (2019)

Article Biochemistry & Molecular Biology

Liproxstatin-1 protects the mouse myocardium against ischemia/reperfusion injury by decreasing VDAC1 levels and restoring GPX4 levels

Yansheng Feng et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Urology & Nephrology

Lipid Peroxidation Drives Renal Cyst Growth In Vitro through Activation of TMEM16A

Rainer Schreiber et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2019)

Article Biochemistry & Molecular Biology

Imidazole Ketone Erastin Induces Ferroptosis and Slows Tumor Growth in a Mouse Lymphoma Model

Yan Zhang et al.

CELL CHEMICAL BIOLOGY (2019)

Article Cardiac & Cardiovascular Systems

Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes

Yuichi Baba et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2018)

Article Biochemistry & Molecular Biology

Puerarin protects against heart failure induced by pressure overload through mitigation of ferroptosis

Bei Liu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

Michael M. Gaschler et al.

NATURE CHEMICAL BIOLOGY (2018)

Review Cardiac & Cardiovascular Systems

Therapeutic approaches for cardiac regeneration and repair

Hisayuki Hashimoto et al.

NATURE REVIEWS CARDIOLOGY (2018)

Review Cell Biology

Ferritinophagy/ferroptosis: Iron-related newcomers in human diseases

Mingzhu Tang et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Review Pharmacology & Pharmacy

miR-133: A Suppressor of Cardiac Remodeling?

Ning Li et al.

FRONTIERS IN PHARMACOLOGY (2018)

Article Cardiac & Cardiovascular Systems

Iron-regulatory proteins secure iron availability in cardiomyocytes to prevent heart failure

Saba Haddad et al.

EUROPEAN HEART JOURNAL (2017)

Article Biochemistry & Molecular Biology

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Valerian E. Kagan et al.

NATURE CHEMICAL BIOLOGY (2017)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Immunology

Ferroptosis: bug or feature?

Scott J. Dixon

IMMUNOLOGICAL REVIEWS (2017)

Article Biochemistry & Molecular Biology

The Construction and Characterization of Mitochondrial Ferritin Overexpressing Mice

Xin Li et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)

Review Biochemistry & Molecular Biology

Iron and Ferroptosis: A Still Ill-Defined Liaison

Sebastian Doll et al.

IUBMB LIFE (2017)

Article Biochemistry & Molecular Biology

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

Q-z Tuo et al.

MOLECULAR PSYCHIATRY (2017)

Article Multidisciplinary Sciences

Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway

Vasanthi S. Viswanathan et al.

NATURE (2017)

Review Pharmacology & Pharmacy

Ferroptosis Inhibition: Mechanisms and Opportunities

Jose Pedro Friedmann Angeli et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2017)

Review Biochemistry & Molecular Biology

How do we fit ferroptosis in the family of regulated cell death?

Howard O. Fearnhead et al.

CELL DEATH AND DIFFERENTIATION (2017)

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Cardiac & Cardiovascular Systems

Passive smoking and mortality from aortic dissection or aneurysm

Tomomi Kihara et al.

ATHEROSCLEROSIS (2017)

Article Biochemistry & Molecular Biology

Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression

Kun Wang et al.

CELL DEATH AND DIFFERENTIATION (2017)

Article Medicine, Research & Experimental

Inhibition of neuronal ferroptosis protects hemorrhagic brain

Qian Li et al.

JCI INSIGHT (2017)

Article Cell Biology

Autophagy promotes ferroptosis by degradation of ferritin

Wen Hou et al.

AUTOPHAGY (2016)

Review Biochemistry & Molecular Biology

Ferroptosis: process and function

Y. Xie et al.

CELL DEATH AND DIFFERENTIATION (2016)

Article Cardiac & Cardiovascular Systems

Role of cell death in the progression of heart failure

Gordon W. Moe et al.

HEART FAILURE REVIEWS (2016)

Article Multidisciplinary Sciences

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

Wan Seok Yang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemistry & Molecular Biology

Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death

Scott J. Dixon et al.

ACS CHEMICAL BIOLOGY (2015)

Review Biochemistry & Molecular Biology

Mammalian lipoxygenases and their biological relevance

Hartmut Kuhn et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2015)

Review Cell Biology

Ironing out Ferroportin

Hal Drakesmith et al.

CELL METABOLISM (2015)

Article Biochemistry & Molecular Biology

Glutaminolysis and Transferrin Regulate Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2015)

Article Biochemistry & Molecular Biology

HSPB1 as a novel regulator of ferroptotic cancer cell death

X. Sun et al.

ONCOGENE (2015)

Review Biochemistry & Molecular Biology

Essential versus accessory aspects of cell death: recommendations of the NCCD 2015

L. Galluzzi et al.

CELL DEATH AND DIFFERENTIATION (2015)

Review Cardiac & Cardiovascular Systems

Cardiac Involvement in Hemochromatosis

Vinay Gulati et al.

CARDIOLOGY IN REVIEW (2014)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Review Biochemistry & Molecular Biology

Lipid peroxidation generates biologically active phospholipids including oxidatively N-modified phospholipids

Sean S. Davies et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2014)

Review Endocrinology & Metabolism

Molecular mechanisms of diabetic cardiomyopathy

Heiko Bugger et al.

DIABETOLOGIA (2014)

Article Cardiac & Cardiovascular Systems

Report from a consensus conference on primary graft dysfunction after cardiac transplantation

Jon Kobashigawa et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

Review Clinical Neurology

The role of iron in brain ageing and neurodegenerative disorders

Roberta Ward et al.

LANCET NEUROLOGY (2014)

Article Multidisciplinary Sciences

Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy

Joseph D. Mancias et al.

NATURE (2014)

Article Cell Biology

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Jose Pedro Friedmann Angeli et al.

NATURE CELL BIOLOGY (2014)

Review Cell Biology

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Antonio Ayala et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

Review Pharmacology & Pharmacy

Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways

Karina Huynh et al.

PHARMACOLOGY & THERAPEUTICS (2014)

Review Clinical Neurology

Iron and Intracerebral Hemorrhage: From Mechanism to Translation

Xiao-Yi Xiong et al.

TRANSLATIONAL STROKE RESEARCH (2014)

Article Cardiac & Cardiovascular Systems

Iron deficiency in chronic heart failure: An international pooled analysis

IJsbrand T. Klip et al.

AMERICAN HEART JOURNAL (2013)

Review Biochemistry & Molecular Biology

Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by antioxidant metal chelators: From ferroptosis to stroke

Rachel E. Speer et al.

FREE RADICAL BIOLOGY AND MEDICINE (2013)

Article Medicine, Research & Experimental

Insulin receptor substrate signaling suppresses neonatal autophagy in the heart

Christian Riehle et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Biochemistry & Molecular Biology

Ferroportin-mediated iron transport: Expression and regulation

Diane M. Ward et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2012)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Review Clinical Neurology

Unifying the definitions of sudden unexpected death in epilepsy

Lina Nashef et al.

EPILEPSIA (2012)

Review Biotechnology & Applied Microbiology

Autophagy modulation as a potential therapeutic target for diverse diseases

David C. Rubinsztein et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

Review Biochemistry & Molecular Biology

Regulation of cellular iron metabolism

Jian Wang et al.

BIOCHEMICAL JOURNAL (2011)

Review Biochemistry & Molecular Biology

Programmed Cell Death in Animal Development and Disease

Yaron Fuchs et al.

Review Chemistry, Multidisciplinary

Free Radical Lipid Peroxidation: Mechanisms and Analysis

Huiyong Yin et al.

CHEMICAL REVIEWS (2011)

Review Biochemistry & Molecular Biology

Lipid peroxidation and neurodegenerative disease

Tanea T. Reed

FREE RADICAL BIOLOGY AND MEDICINE (2011)

Review Physiology

Cell Death in the Pathogenesis of Heart Disease: Mechanisms and Significance

Russell S. Whelan et al.

ANNUAL REVIEW OF PHYSIOLOGY (2010)

Review Pharmacology & Pharmacy

Oxidative stress: a key contributor to diabetic cardiomyopathy

Madhu Khullar et al.

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY (2010)

Review Biochemistry & Molecular Biology

Role of Antioxidants in Redox Regulation of Diabetic Cardiovascular Complications

Belma Turan

CURRENT PHARMACEUTICAL BIOTECHNOLOGY (2010)

Editorial Material Clinical Neurology

Intracerebral haemorrhage: a need for more data and new research directions

Geoffrey A. Donnan et al.

LANCET NEUROLOGY (2010)

Review Clinical Neurology

The complexity of neurobiological processes in acute ischemic stroke

R. Brouns et al.

CLINICAL NEUROLOGY AND NEUROSURGERY (2009)

Review Cell Biology

Apoptosis: controlled demolition at the cellular level

Rebecca C. Taylor et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cardiac & Cardiovascular Systems

European guidelines on cardiovascular disease prevention in clinical practice: executive summary

Ian Graham et al.

EUROPEAN HEART JOURNAL (2007)

Review Cardiac & Cardiovascular Systems

Smoking and aortic diseases

A. I. Kakafika et al.

CIRCULATION JOURNAL (2007)

Article Multidisciplinary Sciences

RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels

Nicholas Yagoda et al.

NATURE (2007)

Review Pharmacology & Pharmacy

Cardiovascular endothelins:: Essential regulators of cardiovascular homeostasis

Friedrich Brunner et al.

PHARMACOLOGY & THERAPEUTICS (2006)

Article Cardiac & Cardiovascular Systems

Fas pathway is a critical mediator of cardiac myocyte death and MI during ischemia-reperfusion in vivo

P Lee et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2003)

Article Endocrinology & Metabolism

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death

F Fiordaliso et al.

DIABETES (2001)

Review Pharmacology & Pharmacy

Cellular responses to DNA damage

CJ Norbury et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY (2001)

Article Cardiac & Cardiovascular Systems

Endotoxemia in transgenic mice overexpressing human glutathione peroxidases

O Mirochnitchenko et al.

CIRCULATION RESEARCH (2000)

Article Cardiac & Cardiovascular Systems

Insulin resistance in chronic heart failure

AJS Coats et al.

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY (2000)