Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.698068
Keywords
osteoimmunology; RANKL/RANK/OPG; rheumatoid arthritis; periodontitis; bone repair; dental implantation
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Funding
- National Natural Science Foundation of China [81701007]
- Sichuan Science and Technology Program [2021YJ0422]
- Fundamental Research Funds for the Central Universities [2018SCUH0006]
- West China School/Hospital of Stomatology Sichuan University [RCDWJS2020-6]
- Basic and Applied Basic Research Projects of West China Hospital of Stomatology of Sichuan University [RD-02-201902]
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This review summarizes the interactions between the skeletal and immune systems, including their co-development and connections at the cellular and molecular levels. Research in osteoimmunology may help uncover the mechanisms of related diseases and provide innovative ideas and solutions.
The skeletal system and immune system seem to be two independent systems. However, there in fact are extensive and multiple crosstalk between them. The concept of osteoimmunology was created to describe those interdisciplinary events, but it has been constantly updated over time. In this review, we summarize the interactions between the skeletal and immune systems in the co-development of the two systems and the progress of certain typical bone abnormalities and bone regeneration on the cellular and molecular levels according to the mainstream novel study. At the end of the review, we also highlighted the possibility of extending the research scope of osteoimmunology to other systemic diseases. In conclusion, we propose that osteoimmunology is a promising perspective to uncover the mechanism of related diseases; meanwhile, a study from the point of view of osteoimmunology may also provide innovative ideas and resolutions to achieve the balance of internal homeostasis.
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