Related references
Note: Only part of the references are listed.Aberrant mitochondrial morphology and function associated with impaired mitophagy and DNM1L-MAPK/ERK signaling are found in aged mutant Parkinsonian LRRK2R1441G mice
Huifang Liu et al.
AUTOPHAGY (2021)
LRRK2 regulates endoplasmic reticulum-mitochondrial tethering through the PERK-mediated ubiquitination pathway
Toshihiko Toyofuku et al.
EMBO JOURNAL (2020)
LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis
Chi G. Weindel et al.
ELIFE (2020)
Mitochondrial Mechanisms of LRRK2 G2019S Penetrance
Sylvie Delcambre et al.
FRONTIERS IN NEUROLOGY (2020)
Poly-ADP-ribose assisted protein localization resolves that DJ-1, but not LRRK2 or α-synuclein, is localized to the mitochondrial matrix
Nelson Osuagwu et al.
PLOS ONE (2019)
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network
Zhiyong Liu et al.
HUMAN MOLECULAR GENETICS (2018)
Parkinson Disease from Mendelian Forms to Genetic Susceptibility: New Molecular Insights into the Neurodegeneration Process
Amin Karimi-Moghadam et al.
CELLULAR AND MOLECULAR NEUROBIOLOGY (2018)
Exhaustion of mitochondrial and autophagic reserve may contribute to the development of LRRK2G2019S-Parkinson's disease
Diana Luz Juarez-Flores et al.
JOURNAL OF TRANSLATIONAL MEDICINE (2018)
The Enzymatic Core of the Parkinson's Disease-Associated Protein LRRK2 Impairs Mitochondria Biogenesis in Aging Yeast
Andreas Aufschnaiter et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
The LRRK2 Variant E193K Prevents Mitochondrial Fission Upon MPP plus Treatment by Altering LRRK2 Binding to DRP1
Maria Perez Carrion et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation
Dong Hwan Ho et al.
EXPERIMENTAL NEUROBIOLOGY (2018)
LRRK2 activation in idiopathic Parkinson's disease
Roberto Di Maio et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Rabs, Membrane Dynamics, and Parkinson's Disease
Bor Luen Tang
JOURNAL OF CELLULAR PHYSIOLOGY (2017)
Inflammatory profile discriminates clinical subtypes in LRRK2-associated Parkinson's disease
K. Brockmann et al.
EUROPEAN JOURNAL OF NEUROLOGY (2017)
LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease
Heyne Lee et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2017)
Fibroblast Biomarkers of Sporadic Parkinson's Disease and LRRK2 Kinase Inhibition
G. A. Smith et al.
MOLECULAR NEUROBIOLOGY (2016)
Immortalized Parkinson's disease lymphocytes have enhanced mitochondrial respiratory activity
Sarah J. Annesley et al.
DISEASE MODELS & MECHANISMS (2016)
LRRK2 at the interface of autophagosomes, endosomes and lysosomes
Dorien A. Roosen et al.
MOLECULAR NEURODEGENERATION (2016)
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Giambattista Guaitoli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
G2385R and I2020T Mutations Increase LRRK2 GTPase Activity
Dong Hwan Ho et al.
BIOMED RESEARCH INTERNATIONAL (2016)
Activation Mechanism of LRRK2 and Its Cellular Functions in Parkinson's Disease
Katharina E. Rosenbusch et al.
PARKINSONS DISEASE (2016)
Cellular processes associated with LRRK2 function and dysfunction
Rebecca Wallings et al.
FEBS JOURNAL (2015)
Association between Parkinson's disease and G2019S and R1441C mutations of the LRRK2 gene
Xiao-Xia Li et al.
EXPERIMENTAL AND THERAPEUTIC MEDICINE (2015)
Does Uncoupling Protein 2 Expression Qualify as Marker of Disease Status in LRRK2-Associated Parkinson's Disease?
Anne Gruenewald et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
ERKed by LRRK2: A cell biological perspective on hereditary and sporadic Parkinson's disease
Manish Verma et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)
LRRK2, a puzzling protein: Insights into Parkinson's disease pathogenesis
A. Raquel Esteves et al.
EXPERIMENTAL NEUROLOGY (2014)
Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
Joao P. L. Daher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
G2019S LRRK2 mutant fibroblasts from Parkinson's disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy
Sokhna M. S. Yakhine-Diop et al.
TOXICOLOGY (2014)
Interaction of LRRK2 with kinase and GTPase signaling cascades
Joon Y. Boon et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2014)
A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies
Sabine Schmitt et al.
ANALYTICAL BIOCHEMISTRY (2013)
The use of streptavidin conjugates as immunoblot loading controls and mitochondrial markers for use with Dictyostelium discoideum
Andrew J. Davidson et al.
BIOTECHNIQUES (2013)
Inhibition of excessive mitochondrial fission reduced aberrant autophagy and neuronal damage caused by LRRK2 G2019S mutation
Yu-Chin Su et al.
HUMAN MOLECULAR GENETICS (2013)
G2019S leucine-rich repeat kinase 2 causes uncoupling protein-mediated mitochondrial depolarization
Tatiana D. Papkovskaia et al.
HUMAN MOLECULAR GENETICS (2012)
LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1
Xinglong Wang et al.
HUMAN MOLECULAR GENETICS (2012)
Leucine-rich repeat kinase 2 disturbs mitochondrial dynamics via Dynamin-like protein
Jingwen Niu et al.
JOURNAL OF NEUROCHEMISTRY (2012)
LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
Mark S. Moehle et al.
JOURNAL OF NEUROSCIENCE (2012)
Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations
Bernd K. Gilsbach et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Mitochondrial Fission, Fusion, and Stress
Richard J. Youle et al.
SCIENCE (2012)
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Zejuan Sheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
Oliver Cooper et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
The Ras related GTPase Miro is not required for mitochondrial transport in Dictyostelium discoideum
Georgia Vlahou et al.
EUROPEAN JOURNAL OF CELL BIOLOGY (2011)
Mutations in LRRK2 increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death
Dario C. Angeles et al.
HUMAN MUTATION (2011)
Regulation of LRRK2 Expression Points to a Functional Role in Human Monocyte Maturation
Jonathan Thevenet et al.
PLOS ONE (2011)
The Dictyostelium model for mitochondrial disease
Lisa M. Francione et al.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY (2011)
Characterization of the Roco Protein Family in Dictyostelium discoideum
Wouter N. van Egmond et al.
EUKARYOTIC CELL (2010)
LRRK2 Is Involved in the IFN-γ Response and Host Response to Pathogens
Agnes Gardet et al.
JOURNAL OF IMMUNOLOGY (2010)
Novel Pathogenic LRRK2 p.Asn1437His Substitution in Familial Parkinson's Disease
Jan O. Aasly et al.
MOVEMENT DISORDERS (2010)
Mitochondrial impairment in patients with Parkinson disease with the G2019S mutation in LRRK2
Heather Mortiboys et al.
NEUROLOGY (2010)
Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein
Xian Lin et al.
NEURON (2009)
The Roco protein family:: a functional perspective
Ignacio Marin et al.
FASEB JOURNAL (2008)
Parkin is recruited selectively to impaired mitochondria and promotes their autophagy
Derek Narendra et al.
JOURNAL OF CELL BIOLOGY (2008)
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
Daniel G. Healy et al.
LANCET NEUROLOGY (2008)
Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
Berta Luzon-Toro et al.
HUMAN MOLECULAR GENETICS (2007)
LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity
Mahaboobi Jaleel et al.
BIOCHEMICAL JOURNAL (2007)
Mutations in LRRK2/dardarin associated with Parkinson disease are more toxic than equivalent mutations in the homologous kinase LRRK1
Elisa Greggio et al.
JOURNAL OF NEUROCHEMISTRY (2007)
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
Andrew B. West et al.
HUMAN MOLECULAR GENETICS (2007)
Localization of LRRK2 to membranous and vesicular structures in mammalian brain
Saskia Biskup et al.
ANNALS OF NEUROLOGY (2006)
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases
Michael T. Lin et al.
NATURE (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease
A Bender et al.
NATURE GENETICS (2006)
LRRK2 in Parkinson's disease: protein domains and functional insights
Ignacio F. Mata et al.
TRENDS IN NEUROSCIENCES (2006)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
The genome of the social amoeba Dictyostelium discoideum
L Eichinger et al.
NATURE (2005)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
On the evolutionary conservation of the cell death pathway:: Mitochondrial release of an apoptosis-inducing factor during Dictyostelium discoideum cell death
D Arnoult et al.
MOLECULAR BIOLOGY OF THE CELL (2001)
Share Paper
