Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.745011
Keywords
Alzheimer's disease; apoptosis; endoplasmic reticulum stress; neuroprotection; unfolded protein response
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Funding
- National Key Research and Development Program of China Stem Cell and Translational Research [2017YFA0105101]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT_16R32]
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDA16030501, XDA16030503]
- Key Research and Development Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory [2018GZR110104004]
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Alzheimer's disease is the most common neurodegenerative disease characterized by progressive cognitive impairment and memory loss. Research indicates that endoplasmic reticulum stress and unfolded protein response play a role in the pathogenesis of AD. Targeting ER stress and ER stress-mediated apoptosis may be effective in treating AD.
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by progressive cognitive impairment and memory loss. So far, the pathogenesis of AD has not been fully understood. Research have shown that endoplasmic reticulum (ER) stress and unfolded protein response (UPR) participate in the occurrence and development of AD. Furthermore, various studies, both in vivo and in vitro, have shown that targeting ER stress and ER stress-mediated apoptosis contribute to the recovery of AD. Thus, targeting ER stress and ER stress-mediated apoptosis may be effective for treating AD. In this review, the molecular mechanism of ER stress and ER stress-mediated apoptosis, as well as the therapeutic effects of some natural compounds and small molecule inhibitors targeting ER stress and ER stress-mediated apoptosis in AD will be introduced.
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