Journal
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
Volume 9, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fcell.2021.669381
Keywords
MPCs; MSCs; bone marrow; adipose tissue; umbilical cord blood; tissue engineering; neo-vascularization
Categories
Funding
- Associazione Italiana contro le Leucemie-Linfomi e Mieloma (A.I.L.)
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Mesangiogenic progenitor cells (MPCs) isolated from human bone marrow mononuclear cells have the ability to differentiate into mesenchymal stromal cells while retaining endothelial differentiative potential. Their power to couple mesengenesis and angiogenesis highlights their tissue regenerative potential, particularly in musculoskeletal tissues.
Mesangiogenic progenitor cells (MPCs) have been isolated from human bone marrow (BM) mononuclear cells. They attracted particular attention for the ability to differentiate into exponentially growing mesenchymal stromal cells while retaining endothelial differentiative potential. MPC power to couple mesengenesis and angiogenesis highlights their tissue regenerative potential and clinical value, with particular reference to musculoskeletal tissues regeneration. BM and adipose tissue represent the most promising adult multipotent cell sources for bone and cartilage repair, although discussion is still open on their respective profitability. Culture determinants, as well as tissues of origin, appeared to strongly affect the regenerative potential of cell preparations, making reliable methods for cell isolation and growth a prerequisite to obtain cell-based medicinal products. Our group had established a definite consistent protocol for MPC culture, and here, we present data showing MPCs to be tissue specific.
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