Journal
JCI INSIGHT
Volume 6, Issue 17, Pages -Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/jci.insight.150909
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Funding
- Duke University School of Medicine
- Duke Microbiome Center
- Children's Miracle Network Hospitals
- Translating Duke Health Children's Health and Discovery Initiative
- US Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development
- NIH/NIAID [U01AI066569, UM1AI104681, UC6AI058607]
- US Defense Advanced Projects Agency [N66001-09-C-2082, HR0011-17-2-0069]
- Virology Quality Assurance [75N93019C00015]
- North Carolina Session Law 2020-4, An Act to Provide Aid to North Carolinians in Response to the Coronavirus Disease 2019 Crisis
- NIH [K23-AI135090]
- Duke Global Health Institute Scholars Program
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The study found that children and adolescents with mild or asymptomatic SARS-CoV-2 infection generate strong and durable humoral immune responses, which may help prevent reinfection.
As SARS-CoV-2 continues to spread globally, questions have emerged regarding the strength and durability of immune responses in specific populations. In this study, we evaluated humoral immune responses in 69 children and adolescents with asymptomatic or mild symptomatic SARS-CoV-2 infection. We detected robust IgM, IgG, and IgA antibody responses to a broad array of SARS-CoV-2 antigens at the time of acute infection and 2 and 4 months after acute infection in all participants. Notably, these antibody responses were associated with virus-neutralizing activity that was still detectable 4 months after acute infection in 94% of children. Moreover, antibody responses and neutralizing activity in sera from children and adolescents were comparable or superior to those observed in sera from 24 adults with mild symptomatic infection. Taken together, these findings indicate that children and adolescents with mild or asymptomatic SARSCoV-2 infection generate robust and durable humoral immune responses that can likely contribute to protection from reinfection.
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