Journal
APPLIED MATERIALS TODAY
Volume 23, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.apmt.2021.101010
Keywords
DNA tetrahedron; Drug delivery; Photosensitizer; Tumor targeting; MUC1; Photodynamic therapy; TMPyP4
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Funding
- National Key R&D Program of China [2019YFA0110600, 2019YFA0110601]
- National Natural Science Foundation of China [81970916, 81671031]
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In this study, a targeted delivery system for new photosensitizers using aptamer-guided DNA tetrahedra was developed to selectively deliver TMPyP4 to MUC1-positive cancer cells. The system promoted the production of reactive oxygen species and cytotoxicity in MUC1-positive cells, demonstrating a potential improvement in photodynamic therapy efficacy.
Photosensitizers are crucial for photodynamic therapy. However, conventional photosensitizers have poor selectivity, and their targeted delivery by nanocarriers has become a major research focus. The aim of this study was to construct a targeted delivery system for new photosensitizers using aptamer-guided DNA tetrahedra. Mucin 1 protein is overexpressed in some cancer cells. The sequence of a Mucin 1 aptamer (MUC1) was linked to a DNA tetrahedron to form MUC1 aptamer-modified tetrahedral nanostructures (MUC1-TDNs) for the selective targeting of MUC1-positive tumor cells. The photosensitizer, TMPyP4, was loaded into MUC1-TDNs owing to the high affinity of TMPyP4 for DNA; consequently, a targeted photosensitizer delivery system (MUC1-TDNs-TMPyP4, MTT) was obtained. This system allowed for the selective delivery of TMPyP4 to MUC1-positive cancer cells. Moreover, MTT promoted the production of reactive oxygen species as well as cytotoxicity in MUC1-positive cells, while less killing effect were observed in MUC1-negative cells. We designed a MUC1-targeted delivery system of photosensitizers based on DNA tetrahedron, thus providing a new approach for the targeted release of photosensitizers. (c) 2021 Published by Elsevier Ltd.
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