4.7 Article

Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients

Related references

Note: Only part of the references are listed.
Article Immunology

Independent Side-by-Side Validation and Comparison of 4 Serological Platforms for SARS-CoV-2 Antibody Testing

Bernd Jahrsdoerfer et al.

Summary: This study provides a comparative validation of 4 anti-SARS-CoV-2 platforms, with Euroimmun and Roche platforms showing the highest sensitivities for screening individuals at increased risk of SARS-CoV-2 infections.

JOURNAL OF INFECTIOUS DISEASES (2021)

Article Biochemistry & Molecular Biology

Functional SARS-CoV-2-Specific Immune Memory Persists after Mild COVID-19

Lauren B. Rodda et al.

Summary: The study found that individuals recovered from mild COVID-19 develop sustained SARS-CoV-2-specific immunological memory for at least 3 months, including immunoglobulin antibodies, neutralizing plasma, and memory B and T cells. These memory lymphocytes exhibit potent antiviral function, aiding in immune defense.
Article Urology & Nephrology

Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease

Eoin D. O'Sullivan et al.

Summary: Patients with chronic kidney disease (CKD) infected with SARS-CoV-2 take a longer time to achieve sequential negative nasopharyngeal swab results in hospital, compared to those without CKD, due to altered immune milieu and declining renal function.

NEPHROLOGY (2021)

Letter Medicine, General & Internal

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

Alicia T. Widge et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Medicine, General & Internal

Antibody Status and Incidence of SARS-CoV-2 Infection in Health Care Workers

S. F. Lumley et al.

Summary: In a longitudinal study of seropositive and seronegative health care workers undergoing asymptomatic and symptomatic SARS-CoV-2 testing, the presence of anti-spike or anti-nucleocapsid IgG antibodies was associated with a substantially reduced risk of SARS-CoV-2 reinfection in the ensuing 6 months.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Multidisciplinary Sciences

Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection

Jennifer M. Dan et al.

Summary: Different components of immune memory to SARS-CoV-2 exhibit distinct kinetics, with antibodies and spike-specific memory B cells remaining relatively stable over 6 months, while CD4(+) T cells and CD8(+) T cells declining with a half-life of 3 to 5 months after infection.

SCIENCE (2021)

Letter Medicine, General & Internal

Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals

Charlotte Manisty et al.

LANCET (2021)

Article Multidisciplinary Sciences

mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

Zijun Wang et al.

Summary: Volunteers who received the Moderna or Pfizer-BioNTech vaccine showed high levels of antibodies and memory B cell responses against SARS-CoV-2, with activity similar to individuals who had recovered from natural infection. However, their efficacy against specific SARS-CoV-2 variants was reduced, indicating a potential need for periodic updates to mRNA vaccines to maintain clinical efficacy.

NATURE (2021)

Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Letter Medicine, General & Internal

Antibody Responses in Seropositive Persons after a Single Dose of SARS-CoV-2 mRNA Vaccine

Florian Krammer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Urology & Nephrology

Humoral Response to the Pfizer BNT162b2 Vaccine in Patients Undergoing Maintenance Hemodialysis

Ayelet Grupper et al.

Summary: Patients on maintenance hemodialysis showed a significantly lower humoral response following the BNT162b2 vaccine compared to the control group, with age being an important factor in the humoral response.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2021)

Letter Medicine, General & Internal

Immunogenicity of a Single Dose of SARS-CoV-2 Messenger RNA Vaccine in Solid Organ Transplant Recipients

Brian J. Boyarsky et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2021)

Article Immunology

Characterization of the SARS-CoV-2 Neutralization Potential of COVID-19-Convalescent Donors

Bernd Jahrsdoerfer et al.

Summary: The study revealed that SARS-CoV-2 neutralization titers remain stable or even increase for at least seven months after diagnosis, showing a positive correlation with age, symptom number, and specific antigen presence. Platform validation indicated the wild-type virus and surrogate neutralization tests had the highest assay performances, but the selection of cutoff titers significantly affected the evaluation of neutralization potency.

JOURNAL OF IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

SARS-CoV-2 in severe COVID-19 induces a TGF-β-dominated chronic immune response that does not target itself

Marta Ferreira-Gomes et al.

Summary: The study found that in severe COVID-19 patients, plasmablasts shift from IFN to TGF-beta instruction to produce IgA antibodies that are not specific to dominant SARS-CoV-2 antigens.

NATURE COMMUNICATIONS (2021)

Article Immunology

Distinct antibody and memory B cell responses in SARS-CoV-2 naive and recovered individuals after mRNA vaccination

Rishi R. Goel et al.

Summary: mRNA vaccines exhibit robust serological and cellular priming, with naïve individuals requiring two doses for optimal antibody responses, especially against the B.1.351 variant. Memory B cells specific for spike protein and RBD were efficiently primed by vaccination, while recovered individuals showed significant boosting after the first dose, correlating with preexisting memory B cell levels. Identifying distinct responses based on prior SARS-CoV-2 exposure suggests that recovered subjects may only need one vaccine dose for peak responses, which can inform vaccine distribution strategies in resource-limited settings.

SCIENCE IMMUNOLOGY (2021)

Article Multidisciplinary Sciences

COVID-19 vaccine BNT162b1 elicits human antibody and TH1 T cell responses

Ugur Sahin et al.

NATURE (2020)

Article Transplantation

COVID-19-related mortality in kidney transplant and dialysis patients: results of the ERACODA collaboration

Luuk B. Hilbrands et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2020)

Article Urology & Nephrology

Immune Dysfunction and Risk of Infection in Chronic Kidney Disease

Maaz Syed-Ahmed et al.

ADVANCES IN CHRONIC KIDNEY DISEASE (2019)

Article Immunology

Circulating Pentraxin3-Specific B Cells Are Decreased in Lupus Nephritis

Mariele Gatto et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Immunology

The calcineurin inhibitor Tacrolimus specifically suppresses human T Follicular helper cells

Elizabeth F. Wallin et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Immunology

CD19+ B-Cells, a New Biomarker of Mortality in Hemodialysis Patients

Maria Molina et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Biochemical Research Methods

Simultaneous epitope and transcriptome measurement in single cells

Marlon Stoeckius et al.

NATURE METHODS (2017)

Article Biotechnology & Applied Microbiology

Polysaccharide-specific B cell responses to vaccination in humans

Ruth Mitchell et al.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2014)

Review Urology & Nephrology

Immune cell dysfunction and inflammation in end-stage renal disease

Michiel G. H. Betjes

NATURE REVIEWS NEPHROLOGY (2013)

Article Biochemistry & Molecular Biology

Tacrolimus differentially regulates the proliferation of conventional and regulatory CD4+ T cells

Kazue Kogina et al.

MOLECULES AND CELLS (2009)

Review Urology & Nephrology

Aspects of immune dysfunction in end-stage renal disease

Sawako Kato et al.

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2008)