Journal
SCIENCE IMMUNOLOGY
Volume 6, Issue 61, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciimmunol.abg5669
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Funding
- Howard Hughes Medical Institute
- NIAID [AI057229]
- Bill and Melinda Gates Foundation [OPP1113682]
- ITI-YIA
- Sean N Parker Center
- Sunshine Foundation
- [U01 AI140498]
- Bill and Melinda Gates Foundation [OPP1113682] Funding Source: Bill and Melinda Gates Foundation
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The study suggests that CD8(+) T cells with conserved specificities are more abundant in COVID-19 patients with mild disease, indicating a potential protective role.
A central feature of the SARS-CoV-2 pandemic is that some individuals become severely ill or die, whereas others have only a mild disease course or are asymptomatic. Here we report development of an improved multimeric alpha beta T cell staining reagent platform, with each maxi-ferritin spheromer displaying 12 peptideMHC complexes. Spheromers stain specific T cells more efficiently than peptide-MHC tetramers and capture a broader portion of the sequence repertoire for a given peptide-MHC. Analyzing the response in unexposed individuals, we find that T cells recognizing peptides conserved amongst coronaviruses are more abundant and tend to have a memory phenotype, compared to those unique to SARS-CoV-2. Significantly, CD8(+) T cells with these conserved specificities are much more abundant in COVID-19 patients with mild disease versus those with a more severe illness, suggesting a protective role.
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