Journal
RESEARCH
Volume 2021, Issue -, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.34133/2021/9898769
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Funding
- National Natural Science Foundation of China [81930121]
- National Key Research and Development Program of China [2018YFA0107902]
- Major Basic Research Project of Science and Technology of Yunnan [202001BC070001]
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Nonhuman primate models play an increasingly indispensable role in translational medicine research, with unique advantages in mimicking clinical patients, although there is still a remaining gap between basic research of NHP models and translational medicine.
Animal models of human diseases are vital in better understanding the mechanism of pathogenesis and essential for evaluating and validating potential therapeutic interventions. As close relatives of humans, nonhuman primates (NHPs) play an increasingly indispensable role in advancing translational medicine research. In this review, we summarized the progress of NHP models generated by embryo engineering, analyzed their unique advantages in mimicking clinical patients, and discussed the remaining gap between basic research of NHP models to translational medicine.
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