Journal
NATURE BIOMEDICAL ENGINEERING
Volume 5, Issue 12, Pages 1409-1410Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41551-021-00724-x
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Shear stress in tendon cells activates the mechanosensitive ion channel PIEZO1, leading to an influx of calcium that enhances collagen crosslinking and increases tendon stiffness, potentially enhancing jumping performance.
In tendon cells under shear stress, the induction of an influx of calcium by the mechanosensitive ion channel PIEZO1 upregulates collagen crosslinking, which increases tendon stiffness and potentially improves jumping performance.
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