Can Plant Lectins Help to Elucidate Insect Lectin-Mediated Immune Response?

Simple Summary Lectins are proteins that can recognize and selectively bind specific sugar structures. These proteins are present in all kingdoms of life, including plants, animals, fungi and microorganisms and play a role in a broad range of processes. The interactions between lectins and their target carbohydrates play a primordial role in plant and animal immune systems. Despite being the largest and most diverse taxa on earth, the study of lectins and their functions in insects is lagging behind. To study the role of insect lectins in the immune response, plant lectins could provide an interesting tool. Plant lectins have been well characterized and many of them possess immunomodulatory properties in vertebrate cells. The increasing knowledge on the immunomodulatory effects of plant lectins could complement the missing knowledge on the endogenous insect lectins and contribute to understanding the processes and mechanisms by which lectins participate in insect immunity. This review summarizes existing studies of immune responses stimulated by endogenous or exogenous lectins. Lectins are carbohydrate-binding proteins that recognize and selectively bind to specific sugar structures. This group of proteins is widespread in plants, animals, and microorganisms, and exerts a broad range of functions. Many plant lectins were identified as exogenous stimuli of vertebrate immunity. Despite being the largest and most diverse taxon on earth, the study of lectins and their functions in insects is lagging behind. In insects, research on lectins and their biological importance has mainly focused on the C-type lectin (CTL) family, limiting our global understanding of the function of insect lectins and their role in insect immunity. In contrast, plant lectins have been well characterized and the immunomodulatory effects of several plant lectins have been documented extensively in vertebrates. This information could complement the missing knowledge on endogenous insect lectins and contribute to understanding of the processes and mechanisms by which lectins participate in insect immunity. This review summarizes existing studies of immune responses stimulated by endogenous or exogenous lectins. Understanding how lectins modulate insect immune responses can provide insight which, in turn, can help to elaborate novel ideas applicable for the protection of beneficial insects and the development of novel pest control strategies.

Automated summary

Lectins are carbohydrate-binding proteins that recognize and selectively bind specific sugar structures. They are found in plants, animals, and microorganisms, playing important roles in immune systems. While insect lectins are not well studied, plant lectins have been characterized and known to possess immunomodulatory properties in vertebrates. The study of lectins and their functions in insects lags behind, but understanding their role in insect immunity is crucial for the development of pest control strategies.