Budget Impact Analysis of the Introduction of Subcutaneous Infliximab (CT-P13 SC) for the Treatment of Rheumatoid Arthritis in the United Kingdom

Background CT-P13 subcutaneous (SC)-the first and only SC version of infliximab-is approved by the European Medicines Agency for the treatment of rheumatoid arthritis (RA). This new mode of infliximab administration will allow patients to self-inject at home, significantly reducing the number of outpatient visits and costs of intravenous (IV) administration. This paper describes the economic impact of introducing CT-P13 SC to the market from the UK societal perspective. Objective The budget impact analysis was conducted to assess the financial impact of the adoption of CT-P13 SC over a 5-year period. Methods A prevalence-based budget impact model was developed incorporating epidemiological data, administration cost data, and market share data. The analysis compared a world with CT-P13 SC scenario to a world without CT-P13 SC. A sensitivity analysis included dose escalation up to 4.1 mg/kg to reflect the real-world care delivery setting. Results Compared to the world without scenario, the introduction of CT-P13 SC resulted in cost savings of 69.3 pound million in the UK over a 5-year period. In the scenario analysis, the saving increased to 173.5 pound million over 5 years. Conclusion Use of CT-P13 SC may lead to substantial cost savings for the UK society.

Automated summary

The introduction of CT-P13 SC may lead to substantial cost savings for the UK society.