Journal
GASTROENTEROLOGY REPORT
Volume 9, Issue 5, Pages 392-401Publisher
OXFORD UNIV PRESS
DOI: 10.1093/gastro/goab035
Keywords
gut microbiota; functional constipation; bile acids; SCFA; serotonin; traditional Chinese medicine
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Funding
- Clinical Medicine Development Project of Beijing Municipal Administration of Hospitals [ZYLX201411]
- Beijing Municipal Science & Technology Commission [Z201100006820119]
- Beijing Science and technology project [z181100001718218]
- Guangdong Province 'Pearl River Talent Plan' Innovation and Entrepreneurship Team Project [2019ZT08Y464]
- National Key Clinical Discipline of China
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Functional constipation (FC) is associated with abnormal gut microbiota, with a likely bidirectional relationship between the two. Gut microbiota may contribute to FC development through modulation of colonic motility, secretion, and absorption. Treatment with microecological agents can result in compositional and functional changes in the gut microbiota, highlighting the potential therapeutic role of targeting gut microbiota in managing FC.
Functional constipation (FC) is common, yet the etiology is not clear. Accumulating evidence suggests an association between FC and abnormal gut microbiota. The relationship between the gut microbiota and the gut transit is likely bidirectional. This review summarizes the current evidence regarding the impact of gut microbiota on the pathogenesis of FC. By modulating the colonic motility, secretion, and absorption, gut microbiota may contribute to the development of FC through microbial metabolic activities involving bile acids, short-chain fatty acids, 5-hydroxytryptamine, and methane. In support of the key roles of the gut microbiota in FC, treatment with probiotics, prebiotics, synbiotics, and traditional Chinese medicine often result in compositional and functional changes in the gut microbiota. Further studies on the pathogenesis of FC and the therapeutic mechanism of microecological agents will provide a knowledge base for better management of FC.
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