Journal
DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY
Volume 14, Issue -, Pages 2735-2742Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/DMSO.S301090
Keywords
adolescents; secreted frizzled-related protein 5; metabolic syndrome; hyperglycemia; dyslipidemia
Categories
Funding
- 345-talent project plan of Shengjing Hospital of China Medical University
- Department of Education Foundation of Liaoning Province [L2015568]
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In adolescents from Northeast China, lower levels of plasma SFRP5 are strongly associated with increased risk of high fasting plasma glucose and high total cholesterol. This suggests a close relationship between SFRP5 and lipid and glucose metabolism in adolescents.
Purpose: Secreted frizzled-related protein 5 (SFRP5) is a novel anti-inflammatory adipokine that has been associated with various metabolic diseases. However, such relationship among adolescents remains unclear. The purpose of this study was to clarify the relationship between SFRP5 and the components of metabolic syndrome in Chinese adolescents. Patients and Methods: In this cross-sectional study, we included a total of 684 adolescents aged 11-16 years old from Liaoyang city, Liaoning province, China. The ELISA kits were implemented to measure the plasma SFRP5 and high-sensitivity C-reactive protein. Serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and high-density lipoprotein cholesterol (HDL-C), serum uric acid (UA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), fasting plasma glucose (FPG), and fasting serum insulin (FINS) were also measured. Results: The multivariate logistic regression analysis showed that low SFRP5 level were an independent risk factor of high FPG [odds ratio (OR)=5.31, 95% confidence interval (CI): 1.85-15.22, P<0.01] and high TC (OR=1.73, 95% CI: 1.01-2.96, P<0.05) when adjusting for age, sex, family history of diabetes, body mass index, and high-sensitivity C-reactive protein. Conclusion: The lower level of SFRP5 is strongly related to lipid and glucose metabolism among adolescents in Northeast China. The risk of high fasting plasma glucose and high total cholesterol increases significantly as the plasma SFRP5 level decreases.
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