Journal
OPEN FORUM INFECTIOUS DISEASES
Volume 8, Issue 8, Pages -Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofab319
Keywords
HIV; latent tuberculosis infection; rifamycin
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Tuberculosis is the leading cause of death in PWH, but diagnosing LTBI and treating with TPT can reduce morbidity and mortality. While isoniazid has been historically recommended for TPT, newer rifamycin-based regimens are safer and may be more effective.
Tuberculosis (TB) remains the leading cause of death among people with human immunodeficiency virus (PWH). The diagnosis of latent TB infection (LTBI) and treatment with TB preventative therapy (TPT) can reduce morbidity and mortality in this population. Historically, isoniazid has been recommended for TPT in PWH due to the absence of drug-drug interactions with most antiretroviral therapy (ART). However, newer rifamycin-based regimens are safer, shorter in duration, associated with improved adherence, and may be as or more effective than isoniazid TPT. Current guidelines have significant heterogeneity in their recommendations for TPT regimens and acceptability of drug interactions with modern ART. In this Infectious Diseases learning unit, we review common questions on diagnosis, treatment, and drug interactions related to the management of LTBI among PWH.
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