4.4 Article

Defective Severe Acute Respiratory Syndrome Coronavirus 2 Immune Responses in an Immunocompromised Individual With Prolonged Viral Replication

Journal

OPEN FORUM INFECTIOUS DISEASES
Volume 8, Issue 9, Pages -

Publisher

OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofab359

Keywords

cellular immunity; COVID-19; humoral immunity; immunocompromise; lymphoma; SARS-CoV-2

Funding

  1. National Health and Medical Research Council (NHMRC) [GNT 1160963, GNT 1142613]
  2. NHMRC [1173871, GNT1196103]
  3. NHMRC EL1 Fellowship [1194036]
  4. Melbourne International Research Scholarship
  5. University of Melbourne
  6. National Health and Medical Research Council of Australia [1194036] Funding Source: NHMRC

Ask authors/readers for more resources

In a lymphoma patient recently treated with PD-1 inhibitor therapy, late onset severe COVID-19 disease and prolonged SARS-CoV-2 replication were observed, with severely impaired immune responses and absence of virus-specific antibodies. This case highlights the challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.
We describe severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific immune responses in a patient with lymphoma and recent programmed death 1 (PD-1) inhibitor therapy with late onset of severe coronavirus disease 2019 disease and prolonged SARS-CoV-2 replication, in comparison to age-matched and immunocompromised controls. High levels of HLA-DR+/CD38(+) activation, interleukin 6, and interleukin 18 in the absence of B cells and PD-1 expression was observed. SARS-CoV-2-specific antibody responses were absent and SARS-CoV-2-specific T cells were minimally detected. This case highlights challenges in managing immunocompromised hosts who may fail to mount effective virus-specific immune responses.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available