4.7 Article

Targeted Radionuclide Therapy Using Auger Electron Emitters: The Quest for the Right Vector and the Right Radionuclide

Related references

Note: Only part of the references are listed.
Review Biology

Exploiting active nuclear import for efficient delivery of Auger electron emitters into the cell nucleus

Andrey A. Rosenkranz et al.

Summary: This review discusses the development of effective anticancer agents for delivering AE emitters into the nuclei of target cancer cells. The use of peptide-based conjugates, nanoparticles, recombinant proteins, and other constructs for targeted intranuclear delivery of AE emitters, as well as their advantages and limitations, are discussed.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2023)

Review Radiology, Nuclear Medicine & Medical Imaging

Potent candidates for Targeted Auger Therapy: Production and radiochemical considerations

Dmitry Filosofov et al.

Summary: This review highlights the importance of selecting suitable radionuclides and designing targeting vectors in the development of efficient radiopharmaceuticals for Targeted Auger Therapy.

NUCLEAR MEDICINE AND BIOLOGY (2021)

Article Medicine, General & Internal

Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer

Oliver Sartor et al.

Summary: The radioligand therapy with Lu-177-PSMA-617 prolonged both imaging-based progression-free survival and overall survival in patients with PSMA-positive metastatic castration-resistant prostate cancer when added to standard care. Adverse events were more common with Lu-177-PSMA-617 but did not significantly impact quality of life.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

Article Radiology, Nuclear Medicine & Medical Imaging

A rapid bead-based radioligand binding assay for the determination of target-binding fraction and quality control of radiopharmaceuticals

Sai Kiran Sharma et al.

NUCLEAR MEDICINE AND BIOLOGY (2019)

Article Medicine, General & Internal

Phase 3 Trial of 177Lu-Dotatate for Midgut Neuroendocrine Tumors

J. Strosberg et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Biochemistry & Molecular Biology

Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects

Salome Paillas et al.

ANTIOXIDANTS & REDOX SIGNALING (2016)

Article Biology

A stochastic cascade model for Auger-electron emitting radionuclides

Boon Q. Lee et al.

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2016)

Article Radiology, Nuclear Medicine & Medical Imaging

DNA damage-centered signaling pathways are effectively activated during low dose-rate Auger radioimmunotherapy

Berengere Piron et al.

NUCLEAR MEDICINE AND BIOLOGY (2014)

Article Radiology, Nuclear Medicine & Medical Imaging

Apoptosis and p53 are not involved in the anti-tumor efficacy of 125I-labeled monoclonal antibodies targeting the cell membrane

Salome Paillas et al.

NUCLEAR MEDICINE AND BIOLOGY (2013)

Review Oncology

What is the role of the Bystander response in radionuclide therapies?

Darren Brady et al.

FRONTIERS IN ONCOLOGY (2013)

Article Radiology, Nuclear Medicine & Medical Imaging

Noninternalizing Monoclonal Antibodies Are Suitable Candidates for 125I Radioimmunotherapy of Small-Volume Peritoneal Carcinomatosis

Lore Santoro et al.

JOURNAL OF NUCLEAR MEDICINE (2009)

Article Oncology

Radioimmunotherapy as a novel treatment regimen:: 125I-labeled monoclonal antibody 425 in the treatment of high-grade brain gliomas

TS Quang et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2004)

Review Radiology, Nuclear Medicine & Medical Imaging

Indium-111-pentetreotide prolongs survival in gastroenteropancreatic malignancies

LB Anthony et al.

SEMINARS IN NUCLEAR MEDICINE (2002)

Article Chemistry, Medicinal

DNA damage induced in cells by γ and UVA radiation as measured by HPLC/GC-MS and HPLC-EC and comet assay

JP Pouget et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2000)