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Polymer-Based Scaffolds Loaded with Aloe vera Extract for the Treatment of Wounds

Journal

PHARMACEUTICS
Volume 13, Issue 7, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics13070961

Keywords

Aloe vera; wound treatment; wound dressings; nanofibers; hydrogels; films; polymers

Funding

  1. Govan Mbeki Research and Development Council
  2. University of Fort Hare
  3. Medical Research Council
  4. National Research Foundation, South Africa

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Aloe vera, a plant extract rich in essential nutrients, has attracted significant attention in wound management for its positive effects on wound healing process. Most currently used wound dressing materials face challenges such as poor antimicrobial properties and weak mechanical performance, requiring better alternative solutions.
The treatment of wounds is one challenging biomedical field due to delayed wound healing common in chronic wounds. Several factors delay wound healing, including microbial infections, malnutrition, underlying physiological conditions, etc. Most of the currently used wound dressing materials suffer from poor antimicrobial properties, poor biodegradability and biocompatibility, and weak mechanical performance. Plant extracts, such as Aloe vera, have attracted significant attention in wound management because of their interesting biological properties. Aloe vera is composed of essential constituents beneficial for the wound healing process, such as amino acids, vitamins C and E, and zinc. Aloe vera influences numerous factors that are involved in wound healing and stimulates accelerated healing. This review reports the therapeutic outcomes of aloe vera extract-loaded polymer-based scaffolds in wound management.

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