Journal
PHARMACEUTICS
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13081239
Keywords
cancer; aptamer; therapy; MUC1; Y; pharmacokinetics
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Funding
- CNPq [301069/2018-2]
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MUC1/Y, a transmembrane glycoprotein overexpressed in epithelial cancers, lacks the variable repeat region and plays a role in oncogenic processes; A DNA aptamer specifically targeting MUC1/Y was developed and shown to inhibit tumor growth both in vitro and in vivo, highlighting the potential of DNA aptamers as a new therapeutic tool for cancer treatment.
MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers; but so far, the precise role of MUC1/Y remains to be elucidated. In this work, we developed and identified a DNA aptamer that specifically recognizes the splice variant MUC1/Y for the first time. The DNA aptamer could bind to a wide variety of human cancer cells, and treatment of MUC1/Y positive cells resulted in reduced growth in vitro. Moreover, MUC1/Y aptamer inhibited the tumour growth of breast cancer cells in vivo. The present study highlights the importance of targeting MUC1/Y for cancer treatment and unravels the suitability of a DNA aptamer to act as a new therapeutic tool.
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