4.7 Article

Microfluidic Technology for the Production of Hybrid Nanomedicines

Journal

PHARMACEUTICS
Volume 13, Issue 9, Pages -

Publisher

MDPI
DOI: 10.3390/pharmaceutics13091495

Keywords

nanomedicine; hybrid nanoparticles; nanoprecipitation; microfluidics

Funding

  1. Ministero degli Esteri e della Cooperazione Internazionale MAECI grant
  2. grant Progetti di ricerca scientifica e tecnologica di grande rilevanza
  3. Ministero degli Esteri
  4. Progetti Italy-USA
  5. Nanomedicine for Blood Brain Barrier (BBB)-crossing in CNS oncologic pathologies [MAE00691612020-06-26]
  6. IMI EU Grants Investigating Mechanisms and Models predictive of accessibility of therapeutics (IM2PACT) Into the Brain IMI2Call 12 [807015]
  7. PorFesr OR-FESR Grant (European Funding for the Regional Development):MAT2REP: Biomateriali multifunzionali per l'autoriparazione di tessuti e organi (2019-2021)

Ask authors/readers for more resources

This study aimed to transfer the production protocol for hybrid NMeds (H-NMeds) from a benchtop nanoprecipitation method to a microfluidic device, showing that microfluidic technology is not a simple transfer of established parameters, with several variables to be taken into account and optimized.
Microfluidic technologies have recently been applied as innovative methods for the production of a variety of nanomedicines (NMeds), demonstrating their potential on a global scale. The capacity to precisely control variables, such as the flow rate ratio, temperature, total flow rate, etc., allows for greater tunability of the NMed systems that are more standardized and automated than the ones obtained by well-known benchtop protocols. However, it is a crucial aspect to be able to obtain NMeds with the same characteristics of the previously optimized ones. In this study, we focused on the transfer of a production protocol for hybrid NMeds (H-NMeds) consisting of PLGA, Cholesterol, and Pluronic(R) F68 from a benchtop nanoprecipitation method to a microfluidic device. For this aim, we modified parameters such as the flow rate ratio, the concentration of core materials in the organic phase, and the ratio between PLGA and Cholesterol in the feeding organic phase. Outputs analysed were the chemico-physical properties, such as size, PDI, and surface charge, the composition in terms of %Cholesterol and residual %Pluronic(R) F68, their stability to lyophilization, and the morphology via atomic force and electron microscopy. On the basis of the results, even if microfluidic technology is one of the unique procedures to obtain industrial production of NMeds, we demonstrated that the translation from a benchtop method to a microfluidic one is not a simple transfer of already established parameters, with several variables to be taken into account and to be optimized.

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