4.7 Article

External Model Performance Evaluation of Twelve Infliximab Population Pharmacokinetic Models in Patients with Inflammatory Bowel Disease

Related references

Note: Only part of the references are listed.
Article Gastroenterology & Hepatology

Cumulative Exposure to Infliximab, But Not Trough Concentrations, Correlates With Rate of Infection

Amandine Landemaine et al.

Summary: In patients treated with infliximab, the risk of infection is correlated with cumulative increase in drug exposure, rather than with the trough concentration of infliximab.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2021)

Article Pharmacology & Pharmacy

Bayes-based dosing of infliximab in inflammatory bowel diseases: Short-term efficacy

Eugenia Santacana Juncosa et al.

Summary: Therapeutic drug monitoring of infliximab combined with Bayesian forecasting methodology can effectively improve clinical responses in patients with inflammatory bowel disease. Optimized dosing of infliximab through this approach helps increase remission rates and overall treatment efficacy for these patients.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Review Pharmacology & Pharmacy

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy

Adam S. Darwich et al.

Summary: Model-informed precision dosing (MIPD) is a modern approach to individualizing drug therapy, focusing on the characteristics of each patient rather than a one-size-fits-all alternative. This review covers the historical perspective on dose variability, technical aspects of MIPD, novel approaches to patient variability, and current debates on MIPD.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021 (2021)

Article Pharmacology & Pharmacy

Optimization of infliximab therapy in inflammatory bowel disease using a dashboard approach-an Indian experience

Mihika B. Dave et al.

Summary: Using the iDose dashboard system to predict infliximab concentrations in patients with inflammatory bowel disease showed clinical efficacy in some patients, aiding in the management of those not responding to conventional dosing.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Gastroenterology & Hepatology

Infliximab clearance decreases in the second and third trimesters of pregnancy in inflammatory bowel disease

Ana-Marija Grisic et al.

Summary: Infliximab clearance decreases significantly in the second and third trimesters of pregnancy, leading to increasing maternal infliximab concentrations in any given regimen. Maternal infliximab levels may be maintained as constant in a de-intensified regimen by therapeutic drug monitoring guidance in inflammatory bowel disease.

UNITED EUROPEAN GASTROENTEROLOGY JOURNAL (2021)

Article Gastroenterology & Hepatology

Efficacy of dashboard driven dosing of infliximab in inflammatory bowel disease patients; a randomized controlled trial

Anne S. Strik et al.

Summary: In IBD patients, using a Bayesian dashboard for IFX dosing can reduce the incidence of LOR and lower fecal calprotectin levels. Additionally, this method can increase the proportion of patients in sustained clinical remission.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2021)

Article Pharmacology & Pharmacy

The effect of aging on infliximab exposure and response in patients with inflammatory bowel diseases

Wannee Kantasiripitak et al.

Summary: This study evaluated the impact of age on infliximab exposure, efficacy, and safety in elderly patients with inflammatory bowel diseases. The results indicated that elderly patients achieved similar infliximab exposure and endoscopic remission compared to nonelderly patients, with age being associated with increased risk of severe adverse events and malignancy but not with infliximab exposure.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection

Alexander Eser et al.

Summary: This study identified predictors of baseline infliximab clearance and early antidrug antibody formation, such as body weight and serum markers. Elevated serum glucose levels were also described as a novel independent predictor of baseline infliximab clearance. These findings may help guide dosing modifications and prophylaxis strategies in clinical practice.

JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Gastroenterology & Hepatology

Improved Population Pharmacokinetic Model for Predicting Optimized Infliximab Exposure in Pediatric Inflammatory Bowel Disease

Laura E. Bauman et al.

INFLAMMATORY BOWEL DISEASES (2020)

Article Medical Laboratory Technology

Predictors of Infliximab Trough Concentrations in Inflammatory Bowel Disease Patients Using a Repeated-Measures Design

Eugenia Santacana et al.

THERAPEUTIC DRUG MONITORING (2020)

Article Pharmacology & Pharmacy

Factors contributing to the systemic clearance of infliximab with long-term administration in Japanese patients with Crohn's disease: Analysis using population pharmacokinetics

Katsuyoshi Matsuoka et al.

INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS (2020)

Article Gastroenterology & Hepatology

Therapeutic thresholds and mechanisms for primary non-response to infliximab in inflammatory bowel disease

Sine Buhl et al.

SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2020)

Article Gastroenterology & Hepatology

Usefulness of population pharmacokinetics to optimize the dosage regimen of infliximab in inflammatory bowel disease patients

Mayte Gil Candel et al.

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS (2020)

Article Pharmacology & Pharmacy

Handling interoccasion variability in model-based dose individualization using therapeutic drug monitoring data

Joao A. Abrantes et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Article Pharmacology & Pharmacy

Pharmacokinetic Parameters of Infliximab Influence the Rate of Relapse After De-Escalation in Adults With Inflammatory Bowel Diseases

Antoine Petitcollin et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2019)

Article Pharmacology & Pharmacy

Optimising infliximab induction dosing for patients with ulcerative colitis

Erwin Dreesen et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2019)

Article Gastroenterology & Hepatology

Characteristics of Faecal Microbiota in Paediatric Crohn's Disease and Their Dynamic Changes During Infliximab Therapy

Yizhong Wang et al.

JOURNAL OF CROHNS & COLITIS (2018)

Review Pharmacology & Pharmacy

Clinical Pharmacokinetics and Pharmacodynamics of Infliximab in the Treatment of Inflammatory Bowel Disease

Amy Hemperly et al.

CLINICAL PHARMACOKINETICS (2018)

Article Gastroenterology & Hepatology

Modeling Immunization To Infliximab in Children With Crohn's Disease Using Population Pharmacokinetics: A Pilot Study

Antoine Petitcollin et al.

INFLAMMATORY BOWEL DISEASES (2018)

Article Pharmacology & Pharmacy

Prediction of Individual Serum Infliximab Concentrations in Inflammatory Bowel Disease by a Bayesian Dashboard System

Alexander Eser et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2018)

Article Astronomy & Astrophysics

Measures of Model Performance Based On the Log Accuracy Ratio

S. K. Morley et al.

SPACE WEATHER-THE INTERNATIONAL JOURNAL OF RESEARCH AND APPLICATIONS (2018)

Editorial Material Gastroenterology & Hepatology

American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease

Joseph D. Feuerstein et al.

GASTROENTEROLOGY (2017)

Article Gastroenterology & Hepatology

Application of Population Pharmacokinetic Modeling for Individualized Infliximab Dosing Strategies in Crohn Disease

Adam Frymoyer et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2017)

Article Medical Laboratory Technology

External Evaluation Of Population Pharmacokinetic Models Of Infliximab In Inflammatory Bowel Disease Patients

Eugènia Santacana et al.

THERAPEUTIC DRUG MONITORING (2017)

Review Medicine, Research & Experimental

Precision Dosing: Public Health Need, Proposed Framework, and Anticipated Impact

Daniel Gonzalez et al.

CTS-CLINICAL AND TRANSLATIONAL SCIENCE (2017)

Article Pharmacology & Pharmacy

Pharmacokinetics of Monoclonal Antibodies

Josiah T. Ryman et al.

CPT-PHARMACOMETRICS & SYSTEMS PHARMACOLOGY (2017)

Article Microbiology

Towards Rational Dosing Algorithms for Vancomycin in Neonates and Infants Based on Population Pharmacokinetic Modeling

Esther J. H. Janssen et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2016)

Article Gastroenterology & Hepatology

Infliximab Dosing Strategies and Predicted Trough Exposure in Children With Crohn Disease

Adam Frymoyer et al.

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION (2016)

Article Medicine, Research & Experimental

The underlying inflammatory chronic disease influences infliximab pharmacokinetics

Christophe Passot et al.

Review Gastroenterology & Hepatology

Loss of Response to Anti-TNFs: Definition, Epidemiology, and Management

Giulia Roda et al.

CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY (2016)

Letter Pharmacology & Pharmacy

A robust estimation of infliximab pharmacokinetic parameters in Crohn's disease

Alexandre Aubourg et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Gastroenterology & Hepatology

Trough Concentrations of Infliximab Guide Dosing for Patients With Inflammatory Bowel Disease

Niels Vande Casteele et al.

GASTROENTEROLOGY (2015)

Article Pharmacology & Pharmacy

Dashboard Systems: Pharmacokinetic/Pharmacodynamic Mediated Dose Optimization for Monoclonal Antibodies

Diane R. Mould et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2015)

Article Gastroenterology & Hepatology

Contribution of infliximab population pharmacokinetic model for dose optimization in ulcerative colitis patients

Eugènia Santacana Juncosa et al.

REVISTA ESPANOLA DE ENFERMEDADES DIGESTIVAS (2015)

Review Biochemical Research Methods

The challenge of indication extrapolation for infliximab biosimilars

Brian G. Feagan et al.

BIOLOGICALS (2014)

Article Pharmacology & Pharmacy

Evidence-Based Morphine Dosing for Postoperative Neonates and Infants

Elke H. J. Krekels et al.

CLINICAL PHARMACOKINETICS (2014)

Review Pharmacology & Pharmacy

Immunogenicity to Therapeutic Proteins: Impact on PK/PD and Efficacy

Narendra Chirmule et al.

AAPS JOURNAL (2012)

Editorial Material Pharmacology & Pharmacy

Monitoring drug therapy

Thierry Buclin et al.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2012)

Article Gastroenterology & Hepatology

Anti-infliximab antibodies in inflammatory bowel disease: prevalence, infusion reactions, immunosuppression and response, a meta-analysis

Lennard Y. W. Lee et al.

EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY (2012)

Article Pharmacology & Pharmacy

Impact of low percentage of data below the quantification limit on parameter estimates of pharmacokinetic models

Xu Steven Xu et al.

JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2011)

Review Gastroenterology & Hepatology

Loss of Response and Requirement of Infliximab Dose Intensification in Crohn's Disease: A Review

Javier P. Gisbert et al.

AMERICAN JOURNAL OF GASTROENTEROLOGY (2009)

Article Pharmacology & Pharmacy

Population pharmacokinetic analysis of infliximab in patients with ulcerative colitis

Adedigbo A. Fasanmade et al.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2009)

Article Medical Laboratory Technology

Infliximab Pharmacokinetics in Inflammatory Bowel Disease Patients

David Ternant et al.

THERAPEUTIC DRUG MONITORING (2009)

Review Pharmacology & Pharmacy

Clinical pharmacokinetics and use of infliximab

Ulrich Klotz et al.

CLINICAL PHARMACOKINETICS (2007)

Article Gastroenterology & Hepatology

Association of trough serum infliximab to clinical outcome after scheduled maintenance treatment for Crohn's disease

Elana A. Maser et al.

CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2006)

Article Computer Science, Interdisciplinary Applications

PsN-Toolkit - A collection of computer intensive statistical methods for non-linear mixed effect modeling using NONMEM

L Lindbom et al.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2005)

Article Computer Science, Interdisciplinary Applications

Perls-speaks-NONMEM (PsN) - a Perl module for NONMEM related programming

L Lindbom et al.

COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE (2004)