Journal
PHARMACEUTICS
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics13060790
Keywords
mechanochemistry; green reactions; pharmaceutical cocrystals
Categories
Funding
- National Autonomous University of Mexico [PAPIIT-DGAPA IT200920]
- PAPIIT-DGAPA-UNAM [PAPIIT IN210520]
- CONACYT [A1-S-33933]
- FORDECYT-PRONACES [FON.INST 22/2020 (FOINS 307152)]
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Mechanochemistry is considered an alternative and environmentally friendly synthetic tool that has a significant impact on various chemistry fields, especially in the preparation of pharmaceutical cocrystals. Its advantages include the ability to carry out reactions under solvent-free or minimal solvent conditions, reducing environmental impact and improving efficiency in the synthesis of multicomponent solid forms.
Mechanochemistry is considered an alternative attractive greener approach to prepare diverse molecular compounds and has become an important synthetic tool in different fields (e.g., physics, chemistry, and material science) since is considered an ecofriendly procedure that can be carried out under solvent free conditions or in the presence of minimal quantities of solvent (catalytic amounts). Being able to substitute, in many cases, classical solution reactions often requiring significant amounts of solvents. These sustainable methods have had an enormous impact on a great variety of chemistry fields, including catalysis, organic synthesis, metal complexes formation, preparation of multicomponent pharmaceutical solid forms, etc. In this sense, we are interested in highlighting the advantages of mechanochemical methods on the obtaining of pharmaceutical cocrystals. Hence, in this review, we describe and discuss the relevance of mechanochemical procedures in the formation of multicomponent solid forms focusing on pharmaceutical cocrystals. Additionally, at the end of this paper, we collect a chronological survey of the most representative scientific papers reporting the mechanochemical synthesis of cocrystals.
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