4.7 Article

Highly Potent GalNAc-Conjugated Tiny LNA Anti-miRNA-122 Antisense Oligonucleotides

Related references

Note: Only part of the references are listed.
Article Biochemistry & Molecular Biology

Effect of modular conjugation strategy for N-acetylgalactosamine-targeted antisense oligonucleotides

Tsuyoshi Yamamoto et al.

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS (2020)

Review Biotechnology & Applied Microbiology

Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug

Alexandre J. Debacker et al.

MOLECULAR THERAPY (2020)

Review Chemistry, Multidisciplinary

In vivoandin vitrostudies of antisense oligonucleotides - a review

Anna Kilanowska et al.

RSC ADVANCES (2020)

Review Cell Biology

Regulation of microRNA biogenesis and its crosstalk with other cellular pathways

Thomas Treiber et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Article Medicine, Research & Experimental

GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells

Sabine Sewing et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2019)

Article Pharmacology & Pharmacy

Metabolism and Disposition of Volanesorsen, a 2′-O-(2 methoxyethyl) Antisense Oligonucleotide, Across Species

Noah Post et al.

DRUG METABOLISM AND DISPOSITION (2019)

Article Biochemistry & Molecular Biology

Highly efficient silencing of microRNA by heteroduplex oligonucleotides

Kotaro Yoshioka et al.

NUCLEIC ACIDS RESEARCH (2019)

Article Multidisciplinary Sciences

Selection of GalNAc-conjugated siRNAs with limited off-target-driven rat hepatotoxicity

Maja M. Janas et al.

NATURE COMMUNICATIONS (2018)

Article Biochemistry & Molecular Biology

Cholesterol-GalNAc Dual Conjugation Strategy for Reducing Renal Distribution of Antisense Oligonucleotides

Fumito Wada et al.

NUCLEIC ACID THERAPEUTICS (2018)

Article Biochemistry & Molecular Biology

Serial incorporation of a monovalent GalNAc phosphoramidite unit into hepatocyte-targeting antisense oligonucleotides

Tsuyoshi Yamamoto et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Sensitive and specific miRNA detection method using SplintR Ligase

Jingmin Jin et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Biochemical Research Methods

Efficient Synthesis and Biological Evaluation of 5′-GalNAc Conjugated Antisense Oligonucleotides

Michael E. Ostergaard et al.

BIOCONJUGATE CHEMISTRY (2015)

Article Chemistry, Medicinal

miRNA-based therapies: strategies and delivery platforms for oligonucleotide and non-oligonucleotide agents

Volker Baumann et al.

FUTURE MEDICINAL CHEMISTRY (2014)

Review Gastroenterology & Hepatology

Role of miR-122 and lipid metabolism in HCV infection

Takasuke Fukuhara et al.

JOURNAL OF GASTROENTEROLOGY (2013)

Article Cell Biology

Pharmacological Inhibition of a MicroRNA Family in Nonhuman Primates by a Seed-Targeting 8-Mer AntimiR

Veerle Rottiers et al.

SCIENCE TRANSLATIONAL MEDICINE (2013)

Article Biochemistry & Molecular Biology

Hepatotoxic Potential of Therapeutic Oligonucleotides Can Be Predicted from Their Sequence and Modification Pattern

Peter H. Hagedorn et al.

NUCLEIC ACID THERAPEUTICS (2013)

Article Biochemistry & Molecular Biology

The discovery approaches and detection methods of microRNAs

Yong Huang et al.

MOLECULAR BIOLOGY REPORTS (2011)

Article Genetics & Heredity

Silencing of microRNA families by seed-targeting tiny LNAs

Susanna Obad et al.

NATURE GENETICS (2011)

Review Chemistry, Multidisciplinary

The Therapeutic Potential of MicroRNAs: Disease Modulators and Drug Targets

Ailbhe M. McDermott et al.

PHARMACEUTICAL RESEARCH (2011)

Article Biochemistry & Molecular Biology

microRNA-122 stimulates translation of hepatitis C virus RNA

Jura Inga Henke et al.

EMBO JOURNAL (2008)

Article Multidisciplinary Sciences

LNA-mediated microRNA silencing in non-human primates

Joacim Elmen et al.

NATURE (2008)

Article Biochemistry & Molecular Biology

Antisense oligonucleotides containing locked nucleic acid improve potency but cause significant hepatotoxicity in animals

Eric E. Swayze et al.

NUCLEIC ACIDS RESEARCH (2007)

Article Biochemistry & Molecular Biology

Plasma protein binding of an antisense oligonucleotide targeting human ICAM-1 (ISIS 2302)

Tanya A. Watanabe et al.

OLIGONUCLEOTIDES (2006)

Article Multidisciplinary Sciences

Silencing of microRNAs in vivo with 'antagomirs'

J Krützfeldt et al.

NATURE (2005)

Article Multidisciplinary Sciences

Modulation of hepatitis C virus RNA abundance by a liver-specific microRNA

CL Jopling et al.

SCIENCE (2005)