4.6 Article

Expression and Clinical Significance of Lactate Dehydrogenase A in Colon Adenocarcinoma

Journal

FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -

Publisher

FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.700795

Keywords

colon adenocarcinoma; LDHA; tumor metabolism; tumor immune; therapy

Categories

Funding

  1. National Natural Science Foundation of China [81903032]
  2. China Postdoctoral Science Foundation [2020M672520]
  3. Research Program of Hunan Health Commission, China [202103030659]
  4. Youth Fund of Xiangya Hospital [2018Q011]
  5. Postgraduate Scientific Research Innovation Project of Hunan Province [CX20200260]
  6. Student Innovation Project of Central South University [2020zzts766]
  7. Open Sharing Fund for the Large-scale Instruments and Equipments of Central South University
  8. National Multidisciplinary Cooperative Diagnosis and Treatment Capacity Building Project for Major Diseases (Lung Cancer)

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The study found that the high expression of LDHA in colon adenocarcinoma was associated with poor survival in patients, and closely related to the levels of immune cell infiltration. This indicates the important role of LDHA in the tumorigenesis and prognosis of colon adenocarcinoma.
Lactate dehydrogenase A (LDHA) is an important glycolytic enzyme that promotes glycolysis and plays a crucial role in cancer cell invasion and immune infiltration. However, the relevance of LDHA in colon adenocarcinoma (COAD) remains unclear. In this study, we analyzed the correlation between the expression of LDHA and clinicopathological characteristics in COAD using immunohistochemistry analysis, and then used integrative bioinformatics analyses to further study the function and role of LDHA in COAD. We found that LDHA was highly expressed in COAD tissues compared with adjacent normal tissues, and that COAD patients with high LDHA expression levels showed poor survival. In addition, LDHA expression was closely associated with the immune infiltrating levels of CD8+ T cells, neutrophils, and dendritic cells. Our findings highlight the potential role of LDHA in the tumorigenesis and prognosis of COAD. Furthermore, our results indicate that COAD is a novel immune checkpoint in the diagnosis and treatment of COAD.

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