Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.633852
Keywords
gallbladder cancer; radiomics; computed tomography; lymph node metastasis; nomogram
Categories
Funding
- National Natural Science Foundation of China [81572975]
- Key Research and Development Project of the Science and Technology Department of Zhejiang, China [2015C03053]
- Zhejiang Provincial Program for the Cultivation of High-level Innovative Health talents
Ask authors/readers for more resources
The study developed and validated a nomogram for predicting lymph node metastasis in gallbladder cancer patients based on CT radiomics features and clinical variables. The nomogram showed the best diagnostic efficiency in the training cohort, internal validation cohort, and external validation cohort, indicating its promising potential for preoperative prediction of LN status in GBC patients.
Objectives The aim of the current study was to develop and validate a nomogram based on CT radiomics features and clinical variables for predicting lymph node metastasis (LNM) in gallbladder cancer (GBC). Methods A total of 353 GBC patients from two hospitals were enrolled in this study. A Radscore was developed using least absolute shrinkage and selection operator (LASSO) logistic model based on the radiomics features extracted from the portal venous-phase computed tomography (CT). Four prediction models were constructed based on the training cohort and were validated using internal and external validation cohorts. The most effective model was then selected to build a nomogram. Results The clinical-radiomics nomogram, which comprised Radscore and three clinical variables, showed the best diagnostic efficiency in the training cohort (AUC = 0.851), internal validation cohort (AUC = 0.819), and external validation cohort (AUC = 0.824). Calibration curves showed good discrimination ability of the nomogram using the validation cohorts. Decision curve analysis (DCA) showed that the nomogram had a high clinical utility. Conclusion The findings showed that the clinical-radiomics nomogram based on radiomics features and clinical parameters is a promising tool for preoperative prediction of LN status in patients with GBC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available