The Ratio of Preoperative Serum Biomarkers Predicts Prognosis in Patients With Oral Squamous Cell Carcinoma

Article Biotechnology & Applied Microbiology

Preoperative Platelet-to-Lymphocyte Ratio (PLR) for Predicting the Survival of Stage I-III Gastric Cancer Patients with a MGC Component

Ziyu Zhu et al.

Summary: The preoperative platelet-to-lymphocyte ratio (PLR) is associated with pathological features of mucinous gastric carcinoma and can independently evaluate the survival of patients with this type of cancer.

BIOMED RESEARCH INTERNATIONAL (2021)

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Article Oncology

Contralateral Regional Recurrence in Lateralized or Paramedian Early-Stage Oral Cancer Undergoing Sentinel Lymph Node Biopsy-Comparison to a Historic Elective Neck Dissection Cohort

Rutger Mahieu et al.

Summary: Comparative study on the management strategies for early-stage oral squamous cell carcinoma patients showed that sentinel lymph node biopsy (SLNB) is more effective in controlling the contralateral neck than elective neck dissection (END). The incidence and prognosis of CRR differ between patients detected by SLNB or bilateral END, highlighting the importance of proper staging of the contralateral clinically negative neck.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

The Pre-treatment Lymphocyte-to-Monocyte Ratio Predicts Efficacy in Metastatic Colorectal Cancer Treated With TAS-102 and Bevacizumab

Hidekazu Kuramochi et al.

Summary: The pre-treatment lymphocyte-to-monocyte ratio (LMR) is a valid predictive and prognostic biomarker for metastatic colorectal cancer patients undergoing TAS-102 and bevacizumab treatment, with higher LMR group showing significantly better disease control rate and longer survival compared to the low LMR group.

ANTICANCER RESEARCH (2021)

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Article Oncology

Predictive potential of Nomogram based on GMWG for patients with hepatocellular carcinoma after radical resection

Liying Ren et al.

Summary: The study found that GMWG, NLR, and tumor size were significantly associated with the overall survival of patients with HCC. By developing a nomogram containing these variables, the study demonstrated its high accuracy and clinical utility in predicting the prognosis of HCC patients.

BMC CANCER (2021)

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Article Otorhinolaryngology

Comparing prognostic utility between the 8th edition of TNM staging system and the lymph node ratio for oral squamous cell carcinoma

Giada A. Beltramini et al.

Summary: The lymph node ratio (LNR) has a higher prognostic value in patients with oral squamous cell carcinoma than N classification, but the lack of reliable cutoffs limits its utility in clinical practice.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2021)

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Review Biochemistry & Molecular Biology

Salivary Cytokines as Biomarkers for Oral Squamous Cell Carcinoma: A Systematic Review

Elena Ferrari et al.

Summary: The prognosis of patients with oral squamous carcinoma depends largely on the stage at diagnosis, with early detection being crucial for reducing the need for extensive surgery and improving disease-free survival. Saliva, as a readily available source of biomarkers, is considered ideal for the development of non-invasive and highly accurate diagnostic tests due to its close interaction with oral cells. Cytokines such as IL-6, IL-8, and TNF-alpha present at higher levels in the saliva of OSCC patients compared to healthy controls may serve as the basis for rapid tests for early diagnosis of oral cancer.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Oncology

Improving Risk Stratification of Early Oral Tongue Cancer with TNM-Immune (TNM-I) Staging System

Alhadi Almangush et al.

Summary: The study found that incorporating immune-related parameters into the tumor staging system can better predict the prognosis of early tongue cancer and improve risk assessment. The immune response plays an important role in early OTSCC and helps identify cases with poor survival.

CANCERS (2021)

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Article Oncology

Derivation and Validation of a Prognostic Scoring Model Based on Clinical and Pathological Features for Risk Stratification in Oral Squamous Cell Carcinoma Patients: A Retrospective Multicenter Study

Jiaying Zhou et al.

Summary: The study developed and validated a simple-to-use prognostic scoring model based on clinical and pathological features to predict overall survival of patients with oral squamous cell carcinoma and facilitate personalized treatment planning. The clinical-pathological model exhibited better predictive ability than the pathological model and AJCC TNM staging system, showing superior discriminative power in the external validation cohort.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology