Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.663221
Keywords
ALCL; childhood; miRNA; prognosis; biomarker; RNA-seq
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Funding
- Associazione Italiana per la Ricerca sul Cancro, Milano, Italy [21385, 20052]
- Fondazione Citta della Speranza [19/03]
- Fondazione CARIPARO, Padova, Italy [17/03]
- Italian Ministry of Education, Universities and Research (PRIN) [2017PPS2X4_003]
- Fondazione Roche per la Ricerca, Rome, Italy
- Fondazione Umberto Veronesi, Milano, Italy
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This study identified significant dysregulation of miRNAs in pediatric ALK-positive ALCL through RNA sequencing, with particular focus on the association of miR-214-5p down-regulation with aggressive non-common histology. These findings suggest that the level of miR-214-5p may help refine prognostic stratification in pediatric ALK-positive ALCL.
The unsatisfactory cure rate of relapsing ALK-positive Anaplastic Large-Cell Lymphoma (ALCL) of childhood calls for the identification of new prognostic markers. Here, the small RNA landscape of pediatric ALK-positive ALCL was defined by RNA sequencing. Overall, 121 miRNAs were significantly dysregulated in ALCL compared to non-neoplastic lymph nodes. The most up-regulated miRNA was miR-21-5p, whereas miR-19a-3p and miR-214-5p were reduced in ALCL. Characterization of miRNA expression in cases that relapsed after first line therapy disclosed a significant association between miR-214-5p down-regulation and aggressive non-common histology. Our results suggest that miR-214-5p level may help to refine the prognostic stratification of pediatric ALK-positive ALCL.
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