Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.679244
Keywords
HOTAIR; cancer; prognosis; therapy; potential; drug resistance; survival; knockdown
Categories
Funding
- Natural Science Foundation of Zhejiang Province [LQ21C060003]
- Jin Hua Science and Technology Plan Project [2021-3-148]
- Doctoral Scientific Research Foundation of Zhejiang Normal University [YS304320122]
Ask authors/readers for more resources
Long non-coding RNAs are crucial regulators of gene expression and physiological processes, with HOX transcript antisense RNA (HOTAIR) being an oncogenic lncRNA highly upregulated in various human cancers. Targeting HOTAIR shows therapeutic potential in cancer treatment, with studies focusing on drug resistance, survival, and potential therapies. Preclinical studies are needed to further explore molecular mechanisms underlying HOTAIR dysregulation and efficient drug delivery methods in vivo.
Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of gene expression and physiological processes. LncRNAs are a class of ncRNAs of 200 nucleotides in length. HOX transcript antisense RNA (HOTAIR), a trans-acting lncRNA with regulatory function on transcription, can repress gene expression by recruiting chromatin modifiers. HOTAIR is an oncogenic lncRNA, and numerous studies have determined that HOTAIR is highly upregulated in a wide variety of human cancers. In this review, we briefly summarize the impact of lncRNA HOTAIR expression and functions on different human solid tumors, and emphasize the potential of HOTAIR on tumor prognosis and therapy. Here, we review the recent studies that highlight the prognostic potential of HOTAIR in drug resistance and survival, and the progress of therapies developed to target HOTAIR to date. Furthermore, targeting HOTAIR results in the suppression of HOTAIR expression or function. Thus, HOTAIR knockdown exhibits great therapeutic potential in various cancers, indicating that targeting lncRNA HOTAIR may serve as a promising strategy for cancer therapy. We also propose that preclinical studies involving HOTAIR are required to provide a better understanding of the exact molecular mechanisms underlying the dysregulation of its expression and function in different human cancers and to explore effective methods of targeting HOTAIR and engineering efficient and targeted drug delivery methods in vivo.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available