Journal
FRONTIERS IN ONCOLOGY
Volume 11, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2021.723707
Keywords
mesenchymal stromal cells; solid tumor; tumor microenvironment; malignant transition; generating process
Categories
Funding
- National Natural Science Foundation of China [81402280]
- Foundation of Open Project from Jiangsu Key Laboratory [XZSYSKF20200001]
- Jiangsu Postdoctoral Research Foundation [1501079A]
- Doctoral Foundation from the First People's Hospital of Lianyungang [BS1503]
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CA-MSCs isolated from various tumors have pro-tumorigenic functions; little is known about their origins and generating process; tumor cells and TME components drive naive MSCs to transition into CA-MSCs.
Cancer-associated mesenchymal stromal cells (CA-MSCs) have been isolated from various types of tumors and are characterized by their vigorous pro-tumorigenic functions. However, very little is known about the origins and generating process of CA-MSCs, which may facilitate the identification of biomarkers for diagnosis or innovative targets for anti-cancer therapy to restrain the tumor growth, spread and chemotherapy resistance. Current evidences have indicated that both distally recruited and local resident MSCs are the primary origins of CA-MSCs. In a tissue type-dependent mode, tumor cells together with the TME components prompt the malignant transition of tumor naive MSCs into CA-MSCs in a direct cell-to-cell contact, paracrine or exosome-mediated manner. In this review, we discuss the transition of phenotypes and functions of naive MSCs into CA-MSCs influenced by tumor cells or non-tumor cells in the TME. The key areas remaining poorly understood are also highlighted and concluded herein.
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