4.6 Review

Current Landscape: The Mechanism and Therapeutic Impact of Obesity for Breast Cancer

Related references

Note: Only part of the references are listed.
Article Oncology

Impact of obesity on safety outcomes and treatment modifications with ado-trastuzumab emtansine in breast cancer patients

Anna Lee et al.

Summary: This study suggests that obese patients receiving T-DM1 may require more treatment modifications due to adverse events compared to non-obese patients. Treatment delays and higher incidence of adverse events were observed in obese patients.

JOURNAL OF ONCOLOGY PHARMACY PRACTICE (2022)

Article Oncology

Obesity and breast cancer risk for pre- and postmenopausal women among over 6 million Korean women

Jae Won Park et al.

Summary: The study found a positive association between obesity and breast cancer risk in postmenopausal Korean women, and an inverse association in premenopausal women.

BREAST CANCER RESEARCH AND TREATMENT (2021)

Article Surgery

Do Obese Breast Cancer Patients Have More Complications and a Longer Length of Stay After Mastectomy Than Nonobese Patients?

Melinda Wang et al.

Summary: Obese breast cancer patients undergoing mastectomy have a higher rate of complications such as infections, flap thrombosis/necrosis, and skin breakdown/wound complications, and a longer hospital length of stay compared to nonobese patients.

AMERICAN SURGEON (2021)

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Article Oncology

COX-2 promotes mammary adipose tissue inflammation, local estrogen biosynthesis, and carcinogenesis in high-sugar/fat diet treated mice

Rosangela Mayer Goncalves et al.

Summary: Obesity is a major risk factor for breast cancer, especially in post-menopausal women. An obesogenic diet has been shown to promote mammary tissue inflammation and local estrogen production, accelerating mammary tumor formation in a COX-2-dependent manner. Treatment with a COX-2 inhibitor was found to decrease inflammation, estrogen levels, and mammary tumor formation, leading to prolonged animal survival.

CANCER LETTERS (2021)

Article Biochemistry & Molecular Biology

CC chemokine ligand 2 (CCL2) stimulates aromatase gene expression in mammary adipose tissue

Gabriela Martinez-Chacon et al.

Summary: Obesity is a risk factor for postmenopausal breast cancer, as obesity-related inflammation upregulates aromatase expression in breast adipose tissue, leading to increased estrogen production and cancer risk. The pro-inflammatory factor CCL2 may regulate aromatase transcription through specific signaling pathways and contribute to the inflammatory environment and aromatase expression in obesity.

FASEB JOURNAL (2021)

Article Oncology

Body mass index and risk of breast cancer molecular subtypes in Korean women: a case-control study

Seok Hun Jeong et al.

BREAST CANCER RESEARCH AND TREATMENT (2020)

Article Oncology

Body Mass Index and Outcomes in Breast Cancer Treated With Breast Conservation

Vikash Patel et al.

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2020)

Article Medicine, Research & Experimental

Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway

Ewa Wilcz-Villega et al.

EMBO MOLECULAR MEDICINE (2020)

Article Medicine, General & Internal

Hospital-diagnosed overweight and obesity related to cancer risk: a 40-year Danish cohort study

S. B. Gribsholt et al.

JOURNAL OF INTERNAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Obesity-Altered Adipose Stem Cells Promote Radiation Resistance of Estrogen Receptor Positive Breast Cancer through Paracrine Signaling

Rachel A. Sabol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Endocrinology & Metabolism

Leptin decreases BC cell susceptibility to NK lysis via PGC1A pathway

Hichem Bouguerra et al.

ENDOCRINE CONNECTIONS (2020)

Article Oncology

Obese adipose tissue extracellular vesicles raise breast cancer cell malignancy

Isadora Ramos-Andrade et al.

ENDOCRINE-RELATED CANCER (2020)

Review Biochemistry & Molecular Biology

Therapeutic aspects of AMPK in breast cancer: Progress, challenges, and future directions

Lavanya Ponnusamy et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2020)

Article Multidisciplinary Sciences

Adipocytes promote breast tumorigenesis through TAZ-dependent secretion of Resistin

Yuhao Gao et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

Effects of obesity on NK cells in a mouse model of postmenopausal breast cancer

Julia Spielmann et al.

SCIENTIFIC REPORTS (2020)

Article Oncology

Impacts of RETN genetic polymorphism on breast cancer development

Chao-Qun Wang et al.

JOURNAL OF CANCER (2020)

Article Oncology

Breast Cancer: Metastasis, Molecular Subtypes, and Overweight and Obesity in Veracruz, Mexico

Carlos Adrian Alarcon Rojas et al.

CLINICAL BREAST CANCER (2019)

Letter Public, Environmental & Occupational Health

Letter regarding article, Associations of obesity and circulating insulin and glucose with breast cancer risk: a Mendelian randomization analysis

Vanessa Y. Tan et al.

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY (2019)

Article Biochemistry & Molecular Biology

Obesity-Altered Adipose Stem Cells Promote ER+ Breast Cancer Metastasis through Estrogen Independent Pathways

Rachel A. Sabol et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Review Oncology

The Impact of Obesity on Breast Cancer Diagnosis and Treatment

Kyuwan Lee et al.

CURRENT ONCOLOGY REPORTS (2019)

Article Oncology

Adult weight gain accelerates the onset of breast cancer

Maria Azrad et al.

BREAST CANCER RESEARCH AND TREATMENT (2019)

Review Biochemistry & Molecular Biology

The Emerging Role of Adiponectin in Female Malignancies

Luca Gelsomino et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Immunology

Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer

Payal Tiwari et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2019)

Article Biotechnology & Applied Microbiology

Genetic and epigenetic modifications of adiponectin gene: Potential association with breast cancer risk

Heba F. Pasha et al.

JOURNAL OF GENE MEDICINE (2019)

Article Oncology

4T1 Mammary Carcinoma Colonization of Metastatic Niches Is Accelerated by Obesity

Gabriela Coeli Menezes Evangelista et al.

FRONTIERS IN ONCOLOGY (2019)

Article Nutrition & Dietetics

Hormonal Therapy Resistance and Breast Cancer: Involvement of Adipocytes and Leptin

Laetitia Delort et al.

NUTRIENTS (2019)

Article Endocrinology & Metabolism

The Role of Adipokines in Breast Cancer: Current Evidence and Perspectives

Gerasimos Socrates Christodoulatos et al.

CURRENT OBESITY REPORTS (2019)

Article Oncology

Weight loss and breast cancer incidence in postmenopausal women

Rowan T. Chlebowski et al.

CANCER (2019)

Article Biochemistry & Molecular Biology

Elevated leptin disrupts epithelial polarity and promotes premalignant alterations in the mammary gland

Iliana Tenvooren et al.

ONCOGENE (2019)

Article Biochemistry & Molecular Biology

Fatty acids: Adiposity and breast cancer chemotherapy, a bad synergy?

Ilze Mentoor et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2019)

Article Nursing

Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss

Sophia A. Stone et al.

WESTERN JOURNAL OF NURSING RESEARCH (2019)

Article Multidisciplinary Sciences

Modulation of the leptin receptors expression in breast cancer cell lines exposed to leptin and tamoxifen

Rodolfo Lopez Linares et al.

SCIENTIFIC REPORTS (2019)

Article Medicine, Research & Experimental

Breast Cancer in Lean Postmenopausal Women Might Have Specific Pathological Features

Toshitaka Uomori et al.

IN VIVO (2019)

Review Medicine, General & Internal

Association of Overweight and Obesity with Breast Cancer During Premenopausal Period in Asia: A Meta-Analysis

Ricvan Dana Nindrea et al.

INTERNATIONAL JOURNAL OF PREVENTIVE MEDICINE (2019)

Article Oncology

Impact of obesity on breast cancer recurrence and minimal residual disease

Brett L. Ecker et al.

BREAST CANCER RESEARCH (2019)

Review Oncology

Translational opportunities for broad-spectrum natural phytochemicals and targeted agent combinations in breast cancer

Lokesh Dalasanur Nagaprashantha et al.

INTERNATIONAL JOURNAL OF CANCER (2018)

Article Nursing

Investigation of a Lifestyle Intervention in Women at High Risk of Breast Cancer

Claire J. Han et al.

WESTERN JOURNAL OF NURSING RESEARCH (2018)

Article Oncology

Exercise and weight loss interventions and miRNA expression in women with breast cancer

Brian D. Adams et al.

BREAST CANCER RESEARCH AND TREATMENT (2018)

Article Oncology

The impact of obesity on outcomes for patients undergoing mastectomy using the ACS-NSQIP data set

Mary Garland et al.

BREAST CANCER RESEARCH AND TREATMENT (2018)

Article Biochemistry & Molecular Biology

Changes in Body Mass Index, Leptin, and Leptin Receptor Polymorphisms and Breast Cancer Risk

Chun-Rong Liu et al.

DNA AND CELL BIOLOGY (2018)

Article Oncology

Serum glucose and insulin and risk of cancers of the breast, endometrium, and ovary in postmenopausal women

Geoffrey C. Kabat et al.

EUROPEAN JOURNAL OF CANCER PREVENTION (2018)

Article Biochemistry & Molecular Biology

Uncoupling effects of estrogen receptor on LKB1/AMPK interaction upon adiponectin exposure in breast cancer

Loredana Mauro et al.

FASEB JOURNAL (2018)

Article Biochemistry & Molecular Biology

IL-10 suppresses TNF-α-induced expression of human aromatase gene in mammary adipose tissue

Gabriela Martinez-Chacon et al.

FASEB JOURNAL (2018)

Article Biochemistry & Molecular Biology

Linoleic acid induces an increased response to insulin in MDA-MB-231 breast cancer cells

Cecilia Rodriguez-Monterrosas et al.

JOURNAL OF CELLULAR BIOCHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Protective properties of n-3 fatty acids and implications in obesity-associated breast cancer

Arwa AL-Jawadi et al.

JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2018)

Article Surgery

Impact of Obesity on Outcomes in Breast Reconstruction: A Systematic Review and Meta-Analysis

Adriana C. Panayi et al.

JOURNAL OF RECONSTRUCTIVE MICROSURGERY (2018)

Article Surgery

Prospective Evaluation of Obese Patients Undergoing Autologous Abdominal Free Flap Breast Reconstruction

Edward I. Chang et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2018)

Article Nutrition & Dietetics

Early breast cancer: why does obesity affect prognosis?

A. Heetun et al.

PROCEEDINGS OF THE NUTRITION SOCIETY (2018)

Article Medicine, Research & Experimental

FGFR1 underlies obesity-associated progression of estrogen receptor-positive breast cancer after estrogen deprivation

Elizabeth A. Wellberg et al.

JCI INSIGHT (2018)

Article Surgery

Late Surgical-Site Infection in Immediate Implant-Based Breast Reconstruction

Indranil Sinha et al.

PLASTIC AND RECONSTRUCTIVE SURGERY (2017)

Article Multidisciplinary Sciences

Mutant p53 potentiates the oncogenic effects of insulin by inhibiting the tumor suppressor DAB2IP

Elena Valentino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Pharmacology & Pharmacy

Leptin, obesity and breast cancer: progress to understanding the molecular connections

Ines Barone et al.

CURRENT OPINION IN PHARMACOLOGY (2016)

Review Biochemistry & Molecular Biology

Aromatase overexpression in dysfunctional adipose tissue links obesity to postmenopausal breast cancer

Xuyi Wang et al.

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2015)

Review Endocrinology & Metabolism

Obesity and cancer-mechanisms underlying tumour progression and recurrence

Jiyoung Park et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Article Oncology

HIF-1α stimulates aromatase expression driven by prostaglandin E2 in breast adipose stroma

Nirukshi U. Samarajeewa et al.

BREAST CANCER RESEARCH (2013)

Review Geriatrics & Gerontology

Interaction between menopausal status and obesity in affecting breast cancer risk

David P. Rose et al.

MATURITAS (2010)