Aspects of high-performance and bio-acceptable magnetic nanoparticles for biomedical application

This review covers extensively the synthesis & surface modification, characterization, and application of magnetic nanoparticles. For biomedical applications, consideration should be given to factors such as design strategies, the synthesis process, coating, and surface passivation. The synthesis method regulates post-synthetic change and specific applications in vitro and in vivo imaging/diagnosis and pharmacotherapy/administration. Special insights have been provided on biodistribution, pharmacokinetics, and toxicity in a living system, which is imperative for their wider application in biology. These nanoparticles can be decorated with multiple contrast agents and thus can also be used as a probe for multi-mode imaging or double/triple imaging, for example, MRI-CT, MRI-PET. Similarly loading with different drug molecules/dye/fluorescent molecules and integration with other carriers have found application not only in locating these particles in vivo but simultaneously target drug delivery/hyperthermia inside the body. Studies are underway to collect the potential of these magnetically driven nanoparticles in various scientific fields such as particle interaction, heat conduction, imaging, and magnetism. Surely, this comprehensive data will help in the further development of advanced techniques for theranostics based on high-performance magnetic nanoparticles and will lead this research area in a new sustainable direction. (C) 2021 Shenyang Pharmaceutical University. Published by Elsevier B.V.

Automated summary

This review extensively covers the synthesis, surface modification, characterization, and applications of magnetic nanoparticles, particularly focusing on their potential in biomedical fields. Factors such as design strategies, synthesis processes, and surface properties play crucial roles in regulating the post-synthetic changes and specific applications of these nanoparticles. Furthermore, understanding the biodistribution, pharmacokinetics, and toxicity of these nanoparticles is essential for their wider biological applications in imaging, diagnosis, and pharmacotherapy.