Journal
ADVANCED MATERIALS TECHNOLOGIES
Volume 6, Issue 10, Pages -Publisher
WILEY
DOI: 10.1002/admt.202100168
Keywords
4D bioprinting; biofabrication; natural origin polymers; stimuli-responsive biomaterials; tissue engineering
Categories
Funding
- European Research Council [ERC-2014-ADG-669858]
- European Union (EU) Horizon 2020 [H2020-NMBP-TR-IND-2020, 953169]
- FCT/MEC [UIDB/50011/2020, UIDP/50011/2020]
- FEDER under the PT2020 Partnership Agreement
- Programa Operacional Competitividade e InternacionalizacAo (POCI), FEDER
- national funds (OE) through FCT/MCTES [PTDC/BTM-MAT/31498/2017, FCT-POCI-01-0145-FEDER-031210, PTDC/BTM-SAL/30503/2017]
- MARGEL project
- FCT [CEECIND/01410/2018]
- MIMETic project
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Leveraging 4D biofabrication for engineering biomimetic living constructs is an emerging strategy for recapitulating native tissue dynamics. Carefully selecting smart materials and cell-supporting functionalities is crucial, with the potential to be widely applied in tissue engineering and regenerative medicine.
Leveraging 4D biofabrication for engineering biomimetic living constructs is rapidly emerging as a valuable strategy for recapitulating native tissue dynamics, via on-demand stimuli, or in a naturally evolving mode. Carefully selecting smart materials with suitable responsiveness and cell-supporting functionalities is crucial to take full operational advantage of this next-generation technology. Recent endeavors combining naturally available polymers or hybrid smart materials improve the potential to manufacture volumetrically defined, cell-rich constructs that may display stimuli-responsive properties, shape memory/shape morphing features, and/or dynamic motion in time. In this review, natural origin biomaterials and the stimuli that can be exploited for granting dynamic morphological features and functionalities post-printing are highlighted. A broad overview of recent reports focusing on 4D-bioprinted constructs for tissue engineering and regenerative medicine is also provided and critically discussed in light of current challenges, as well as foreseeable advances. It is envisioned that upon assurance of key regulatory demands, such technology will become translatable to numerous biomedical applications that require fabrication of constructs with dynamic functionality.
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