Adhesive Capable of Underwater Adhesion and Wound Hemostasis Prepared Based on Solvent Exchange

Whether used for underwater adhesion or wound hemostasis, adhesives are required to have strong wet adhesion. However, traditional adhesives are difficult to break through the blockade of the hydration interface, so they cannot achieve strong underwater adhesion, and their biological toxicities are also greater, not suitable for wound hemostasis. In this work, small molecule polyethylene glycol diacrylate (PEGDA-200) and dopamine (DA) with good biocompatibility are used as raw materials to synthesize a long chain polymer (PDDA) with hydrophobic backbone and hydrophilic group through the Michael addition reaction. Based on the hydrogen bond interaction between PDDA and silicotungstic acid (SiW) and the solvent exchange between dimethyl sulfoxide and water, the two are successfully caused to agglomerate and form a viscous aggregate (PDDA-SiW). PDDA-SiW not only has strong underwater adhesion to various substrates, but also has strong adhesion and readhesion to fresh pigskins. In addition, PDDA-SiW also has very low hemolysis and cytotoxicity and strong antibacterial properties, and it is a very good underwater adhesion and wound hemostatic material.

Automated summary

In this study, a long chain polymer (PDDA) with hydrophobic backbone and hydrophilic group was synthesized using small molecule polyethylene glycol diacrylate (PEGDA-200) and dopamine (DA) as raw materials through the Michael addition reaction. By utilizing hydrogen bond interaction and solvent exchange, a viscous aggregate (PDDA-SiW) was successfully formed, exhibiting strong underwater adhesion to various substrates and high adhesion to fresh pigskins. Additionally, PDDA-SiW showed low hemolysis and cytotoxicity, strong antibacterial properties, making it an excellent material for underwater adhesion and wound hemostasis.