4.6 Article

Evaluation of Micro Satellite Instability and Mismatch Repair Status in Different Solid Tumors: A Multicenter Analysis in a Real World Setting

Related references

Note: Only part of the references are listed.
Article Pathology

Detection of microsatellite instability in a panel of solid tumours with the Idylla MSI Test using extracted DNA

Adrien Pecriaux et al.

Summary: The aim of the study was to evaluate the Idylla MSI Test by Biocartis for MSI analysis, which can be completed within 150 minutes. The results showed high sensitivity (94%) and specificity (100%), with a few invalid and false-negative results observed. The experiment also emphasized the importance of DNA quantity loaded into the cartridge, with a LOD between 4% and 8%.

JOURNAL OF CLINICAL PATHOLOGY (2021)

Article Cell Biology

The diversity of tumours with microsatellite instability: molecular mechanisms and impact upon microsatellite instability testing and mismatch repair protein immunohistochemistry

Jinru Shia

Summary: Microsatellite instability (MSI) is recognized as a diverse molecular phenotype in human neoplasms, with variations in genotype and phenotype within and across tumor types. Advances in understanding this diversity have been made, but its potential impact on the effective use of current MSI detection tools is significant.

HISTOPATHOLOGY (2021)

Article Pathology

Idylla microsatellite instability assay versus mismatch repair immunohistochemistry: a retrospective comparison in gastric adenocarcinoma

Luke Farmkiss et al.

Summary: Up to 22% of gastric adenocarcinomas belong to the microsatellite instability (MSI) subtype, which responds to novel immunotherapies but may not benefit from conventional chemotherapy. Screening for MSI subtype in gastric adenocarcinoma can help detect inherited diseases and identify at-risk relatives. MSI testing and mismatch repair (MMR) immunohistochemistry (IHC) are established methods for detecting this subtype, with the best results achieved through their combined use.

JOURNAL OF CLINICAL PATHOLOGY (2021)

Article Oncology

Predictive Biomarkers for Immune Checkpoint Inhibitors in Metastatic Breast Cancer

Abirami Sivapiragasam et al.

Summary: In this study, a large dataset of female metastatic breast cancers was analyzed using comprehensive genomic profiling to identify potential biomarkers associated with immunotherapy responsiveness. The study found various markers such as CD274 amplification, TMB, and MSI that may indicate response to immune checkpoint inhibitors in MBC. Furthermore, CGP shows promise in identifying genomic alterations linked to response and resistance to ICPI in MBC.

CANCER MEDICINE (2021)

Review Genetics & Heredity

Immune-Based Therapies and the Role of Microsatellite Instability in Pancreatic Cancer

Michele Ghidini et al.

Summary: Pancreatic cancer has low survival rates and requires earlier diagnosis and stratified treatment; a minority of pancreatic cancer patients have microsatellite instability, which has been studied in gastrointestinal tumors; immune-based therapies may offer treatment opportunities for pancreatic cancer patients with microsatellite instability.

GENES (2021)

Review Oncology

Diagnosis of Lynch Syndrome and Strategies to Distinguish Lynch-Related Tumors from Sporadic MSI/dMMR Tumors

Julie Leclerc et al.

Summary: Microsatellite instability (MSI) is a hallmark of Lynch syndrome (LS)-related tumors, but it is not exclusive to LS, as most MSI/mismatch repair-deficient (dMMR) tumors are sporadic. Advances in diagnostic and screening strategies have evolved in recent years, focusing on identifying LS patients and distinguishing LS-related from sporadic MSI tumors. Discussions on pitfalls associated with current strategies aim to improve LS diagnosis and prevent inappropriate clinical management.

CANCERS (2021)

Article Oncology

Managing Difficulties of Microsatellite Instability Testing in Endometrial Cancer-Limitations and Advantages of Four Different PCR-Based Approaches

Janna Siemanowski et al.

Summary: This study focused on challenges in microsatellite instability testing in endometrial cancer and compared four different PCR-based approaches to improve MSI testing in future screenings. By directly comparing the systems, the study was able to highlight the advantages and limitations of each.

CANCERS (2021)

Article Pathology

Detection of microsatellite instability with Idylla MSI assay in colorectal and endometrial cancer

Iiris Ukkola et al.

Summary: Universal testing of microsatellite instability (MSI) is recommended for colorectal cancer (CRC) and endometrial cancer (EC) to screen for Lynch syndrome and to aid in assessing prognosis and optimal treatment. The Idylla MSI test offers a sensitive and specific method for CRC diagnostics but is less sensitive in EC samples, especially in the case of MSH6 deficiency.

VIRCHOWS ARCHIV (2021)

Article Pathology

Multi-center real-world comparison of the fully automated Idylla™ microsatellite instability assay with routine molecular methods and immunohistochemistry on formalin-fixed paraffin-embedded tissue of colorectal cancer

Ana Velasco et al.

Summary: The Idylla (TM) MSI Assay has a lower failure rate and high concordance levels compared to routine diagnostic tests.

VIRCHOWS ARCHIV (2021)

Review Oncology

Microsatellite instability: a review of what the oncologist should know

Kai Li et al.

CANCER CELL INTERNATIONAL (2020)

Article Pathology

Novel Biocartis Idylla™ cartridge-based assay for detection of microsatellite instability in colorectal cancer tissues

Andres E. Mindiola-Romero et al.

EXPERIMENTAL AND MOLECULAR PATHOLOGY (2020)

Review Biotechnology & Applied Microbiology

Patients Selection for Immunotherapy in Solid Tumors: Overcome the Naive Vision of a Single Biomarker

Diego Signorelli et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Pathology

Clinical Utility of a Fully Automated Microsatellite Instability Test with Minimal Hands-on Time

Miseon Lee et al.

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2019)

Article Gastroenterology & Hepatology

Prevalence of Microsatellite Instability in Intraductal Papillary Mucinous Neoplasms of the Pancreas

Renato M. Lupinacci et al.

GASTROENTEROLOGY (2018)

Review Pharmacology & Pharmacy

DNA mismatch repair in cancer

Marina Baretti et al.

PHARMACOLOGY & THERAPEUTICS (2018)

Letter Pathology

Microsatellite instability evaluation by automated microfluidic electrophoresis: an update

Francesco Pepe et al.

JOURNAL OF CLINICAL PATHOLOGY (2017)

Article Oncology

Can Microsatellite Status of Colorectal Cancer Be Reliably Assessed after Neoadjuvant Therapy?

Jennifer B. Goldstein et al.

CLINICAL CANCER RESEARCH (2017)

Article Multidisciplinary Sciences

Comprehensive molecular characterization of gastric adenocarcinoma

Adam J. Bass et al.

NATURE (2014)

Article Multidisciplinary Sciences

Integrated genomic characterization of endometrial carcinoma

Gad Getz et al.

NATURE (2013)

Article Cell Biology

Postreplicative Mismatch Repair

Josef Jiricny

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)

Article Medicine, General & Internal

Identification of Lynch Syndrome Among Patients With Colorectal Cancer

Leticia Moreira et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2012)

Article Pathology

Neoadjuvant Therapy Induces Loss of MSH6 Expression in Colorectal Carcinoma

Fei Bao et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2010)