Journal
CELLS
Volume 10, Issue 7, Pages -Publisher
MDPI
DOI: 10.3390/cells10071764
Keywords
hypoxia; hypoxia-inducible factors; liver fibrosis; liver fibrogenesis; chronic liver diseases
Categories
Funding
- Associazione Italiana per la Ricerca sul Cancro (AIRC) [20361]
- University of Torino
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Liver fibrosis is a potentially reversible pathophysiological event characterized by excess deposition of extracellular matrix components, which is primarily driven by activated myofibroblasts and other hepatic cell populations involved in chronic liver disease progression. The emerging pathogenic role of hypoxia, hypoxia-inducible factors, and related mediators in the fibrogenic progression of chronic liver diseases is a key focus of research.
Liver fibrosis is a potentially reversible pathophysiological event, leading to excess deposition of extracellular matrix (ECM) components and taking place as the net result of liver fibrogenesis, a dynamic and highly integrated process occurring during chronic liver injury of any etiology. Liver fibrogenesis and fibrosis, together with chronic inflammatory response, are primarily involved in the progression of chronic liver diseases (CLD). As is well known, a major role in fibrogenesis and fibrosis is played by activated myofibroblasts (MFs), as well as by macrophages and other hepatic cell populations involved in CLD progression. In the present review, we will focus the attention on the emerging pathogenic role of hypoxia, hypoxia-inducible factors (HIFs) and related mediators in the fibrogenic progression of CLD.
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