Journal
CELLS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cells10081945
Keywords
circular RNA; epigenetics; alcoholic liver disease; metabolic-associated fatty liver disease; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; hepatitis; liver regeneration; liver cirrhosis; autoimmune liver disease
Categories
Funding
- Natural Science Fund of China [81670551, U1702281, 81873584, 82000613, 82000574]
- Sichuan Science and Technology Program [2020YJ0084, 2021YFS0147]
- National Key R&D Program of China [2017YFA0205404]
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CircRNAs, a type of non-coding RNA, play a crucial role in regulating liver homeostasis and diseases, but their epigenetic mechanisms in chronic liver diseases remain unclear. Research has discussed the role of circRNAs in various non-neoplastic chronic liver diseases, emphasizing the need for further efforts to develop them as novel diagnostics and therapeutics for chronic liver diseases.
Circular RNA (circRNA) is a type of non-coding RNA characterized by a covalently closed continuous loop. CircRNA is generated by pre-mRNA through back-splicing and is probably cleared up by extracellular vesicles. CircRNAs play a pivotal role in the epigenetic regulation of gene expression at transcriptional and post-transcriptional levels. Recently, circRNAs have been demonstrated to be involved in the regulation of liver homeostasis and diseases. However, the epigenetic role and underlying mechanisms of circRNAs in chronic liver diseases remain unclear. This review discussed the role of circRNAs in non-neoplastic chronic liver diseases, including alcoholic liver disease (ALD), metabolic-associated fatty liver disease (MAFLD), viral hepatitis, liver injury and regeneration, liver cirrhosis, and autoimmune liver disease. The review also highlighted that further efforts are urgently needed to develop circRNAs as novel diagnostics and therapeutics for chronic liver diseases.
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