Journal
CELLS
Volume 10, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/cells10092496
Keywords
cartilage repair; chondrocytes; stem cells; articular cartilage; autologous chondrocyte transplantation; regenerative medicine; tissue engineering
Categories
Funding
- European Union [681103]
- H2020 Societal Challenges Programme [681103] Funding Source: H2020 Societal Challenges Programme
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Cell-based therapy is a promising strategy for treating cartilage defects, but the choice of the optimal cell source is complex. Research is currently focusing on different types of cells to objectively assess their advantages and disadvantages in repairing damaged articular cartilage.
Cell-based therapy represents a promising treatment strategy for cartilage defects. Alone or in combination with scaffolds/biological signals, these strategies open many new avenues for cartilage tissue engineering. However, the choice of the optimal cell source is not that straightforward. Currently, various types of differentiated cells (articular and nasal chondrocytes) and stem cells (mesenchymal stem cells, induced pluripotent stem cells) are being researched to objectively assess their merits and disadvantages with respect to the ability to repair damaged articular cartilage. In this paper, we focus on the different cell types used in cartilage treatment, first from a biological scientist's perspective and then from a clinician's standpoint. We compare and analyze the advantages and disadvantages of these cell types and offer a potential outlook for future research and clinical application.
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