Journal
CELLS
Volume 10, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cells10082030
Keywords
the hedgehog pathway; chemotherapy; resistance; gastric cancer; colorectal cancer; pancreatic cancer
Categories
Funding
- Well Center for Pediatric Research
- Jeff Gordon Research Laboratory
- AGA
- Healthcare Initiatives, Inc.
- CTSI Indiana
- National Natural Science Foundation of China [31960153]
Ask authors/readers for more resources
This review focuses on the recent advances in the roles of the hedgehog pathway in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
The hedgehog pathway, which plays a significant role in embryonic development and stem cell regulation, is activated in gastrointestinal cancers. Chemotherapy is widely used in cancer treatment. However, chemoresistance becomes a substantial obstacle in cancer therapy. This review focuses on the recent advances in the hedgehog pathway's roles in drug resistance of gastrointestinal cancers and the novel drugs and strategies targeting hedgehog signaling.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
