Journal
CELLS
Volume 10, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/cells10102513
Keywords
intracerebral hemorrhage; tissue regeneration; neurogenesis; remyelination; angiogenesis; neuroinflammation; drug therapy; stem cells; rehabilitation; biomaterial
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Funding
- National Natural Science Foundation of China [81870942, 81471174, 81520108011]
- National Key Research and Development Program of China [2018YFC1312200]
- Innovation Scientists and Technicians Troop Constructions Projects of Henan Province of China
- Canadian Institutes of Health Sciences
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Despite advancements in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage remains devastating. Utilizing the regenerative potential of the central nervous system may improve outcomes for hemorrhagic stroke patients, but approaches are still nascent in development. This review discusses regenerative phenomena in animal models and human ICH, as well as potential methods to promote tissue regeneration in ICH to stimulate further research in tissue restoration post-ICH.
Despite marked advances in surgical techniques and understanding of secondary brain injury mechanisms, the prognosis of intracerebral hemorrhage (ICH) remains devastating. Harnessing and promoting the regenerative potential of the central nervous system may improve the outcomes of patients with hemorrhagic stroke, but approaches are still in their infancy. In this review, we discuss the regenerative phenomena occurring in animal models and human ICH, provide results related to cellular and molecular mechanisms of the repair process including by microglia, and review potential methods to promote tissue regeneration in ICH. We aim to stimulate research involving tissue restoration after ICH.
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