4.6 Review

Ovarian-Cancer-Associated Extracellular Vesicles: Microenvironmental Regulation and Potential Clinical Applications

Related references

Note: Only part of the references are listed.
Article Oncology

Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small-Cell Lung Cancer Through the miR-638/FAM83F Axis

Ke Fang et al.

Summary: This study uncovered the upregulation of circARHGAP10 in NSCLC and its promotion of proliferation, migration, invasion, and glycolysis of NSCLC cells through serum-derived exosome-mediated miR-638/FAM83F axis.

CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS (2022)

Article Cell Biology

Exosomes in ovarian cancer ascites promote epithelial-mesenchymal transition of ovarian cancer cells by delivery of miR-6780b-5p

Jing Cai et al.

Summary: Poor prognosis of ovarian cancer is mainly due to metastasis, with ascites-derived exosomes playing a role in promoting metastasis through epithelial-mesenchymal transition. The key microRNA miR-6780b-5p in ADEs facilitates cancer metastasis by promoting EMT in ovarian cancer cells, indicating a potential mechanism for ovarian cancer progression.

CELL DEATH & DISEASE (2021)

Article Medicine, General & Internal

Ovarian cancer population screening and mortality after long-term follow-up in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial

Usha Menon et al.

Summary: The long-term follow-up of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) did not show a significant reduction in deaths due to ovarian or tubal cancer with screening. While there was an increase in early-stage cancer detection in the MMS group, it did not translate into lives saved, highlighting the importance of specifying cancer mortality as the primary outcome in screening trials. Consequently, general population screening for ovarian and tubal cancer cannot be recommended.

LANCET (2021)

Article Oncology

Exosomal CD47 Plays an Essential Role in Immune Evasion in Ovarian Cancer

Aasa Shimizu et al.

Summary: The study revealed that overexpression of CD47 in ovarian cancer is associated with poor prognosis; inhibiting exosome secretion or uptake can enhance macrophage phagocytosis of cancer cells, thereby suppressing peritoneal dissemination.

MOLECULAR CANCER RESEARCH (2021)

Review Chemistry, Multidisciplinary

Extracellular Vesicle Nanoarchitectonics for Novel Drug Delivery Applications

Shayna Sharma et al.

Summary: EVs can serve as natural carriers for drug delivery, and their fusion with engineered nanostructures has been proposed to enhance drug loading and achieve site-specific delivery. Challenges such as isolation, heterogeneity, coexistence with biomolecules, and lack of targeted delivery have limited the potential of EVs.

SMALL (2021)

Article Oncology

Extracellular Vesicle Transmission of Chemoresistance to Ovarian Cancer Cells Is Associated with Hypoxia-Induced Expression of Glycolytic Pathway Proteins, and Prediction of Epithelial Ovarian Cancer Disease Recurrence

Mona Alharbi et al.

Summary: Ovarian cancer is one of the most lethal cancers worldwide affecting women, with non-specific early symptoms. sEVs produced under low oxygen tension can induce a metabolic switch in ovarian cancer cells, promoting resistance to carboplatin. The presence of glycolysis pathway proteins in sEVs is closely associated with ovarian cancer recurrence.

CANCERS (2021)

Article Oncology

Genetically Defined Syngeneic Mouse Models of Ovarian Cancer as Tools for the Discovery of Combination Immunothrapy

Sonia Iyer et al.

Summary: The study developed a series of mouse models carrying genotypes of human high-grade serous tubo-ovarian carcinomas (HGSC) that can grow in syngeneic immunocompetent hosts, recapitulating human disease characteristics, including genotype-driven responses to treatment. The research identified follistatin as a driver of resistance to checkpoint inhibitors.

CANCER DISCOVERY (2021)

Review Cell Biology

Tumor microenvironment complexity and therapeutic implications at a glance

Roghayyeh Baghba et al.

CELL COMMUNICATION AND SIGNALING (2020)

Article Reproductive Biology

Serum exosomal microRNA-34a as a potential biomarker in epithelial ovarian cancer

Kazuya Maeda et al.

JOURNAL OF OVARIAN RESEARCH (2020)

Article Multidisciplinary Sciences

Ovarian Cancer Exosomes Trigger Differential Biophysical Response in Tumor-Derived Fibroblasts

Amy H. Lee et al.

SCIENTIFIC REPORTS (2020)

Article Nanoscience & Nanotechnology

miRNa signature in small extracellular vesicles and their association with platinum resistance and cancer recurrence in ovarian cancer

Mona Alharbi et al.

NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE (2020)

Article Cell Biology

Immune (Cell) Derived Exosome Mimetics (IDEM) as a Treatment for Ovarian Cancer

Simone Pisano et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Review Oncology

Exosomes play roles in sequential processes of tumor metastasis

Keyu Li et al.

INTERNATIONAL JOURNAL OF CANCER (2019)

Review Medicine, General & Internal

Epithelial ovarian cancer

Stephanie Lheureux et al.

LANCET (2019)

Review Biochemistry & Molecular Biology

The role of exosomal noncoding RNAs in cancer

Yan Xie et al.

MOLECULAR CANCER (2019)

Article Biochemistry & Molecular Biology

Reassessment of Exosome Composition

Dennis K. Jeppesen et al.

Article Biotechnology & Applied Microbiology

The Effect of Triptolide-Loaded Exosomes on the Proliferation and Apoptosis of Human Ovarian Cancer SKOV3 Cells

Huan Liu et al.

BIOMED RESEARCH INTERNATIONAL (2019)

Article Multidisciplinary Sciences

Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma

Malgorzata Czystowska-Kuzmicz et al.

NATURE COMMUNICATIONS (2019)

Article Multidisciplinary Sciences

3D cell culture stimulates the secretion of in vivo like extracellular vesicles

Sirisha Thippabhotla et al.

SCIENTIFIC REPORTS (2019)

Article Oncology

How to manage lymph nodes in ovarian cancer

Philipp Harter et al.

CANCER (2019)

Review Medical Laboratory Technology

Liquid biopsy in ovarian cancer: the potential of circulating miRNAs and exosomes

Lydia Giannopoulou et al.

TRANSLATIONAL RESEARCH (2019)

Article Biotechnology & Applied Microbiology

Exosomes-Derived Long Non-Coding RNA HOTAIR Reduces Laryngeal Cancer Radiosensitivity by Regulating microRNA-454-3p/E2F2 Axis

Xiangyan Cui et al.

ONCOTARGETS AND THERAPY (2019)

Article Oncology

Ovarian cancer-derived extracellular vesicles affect normal human fibroblast behavior

Ilaria Giusti et al.

CANCER BIOLOGY & THERAPY (2018)

Review Pharmacology & Pharmacy

The latest animal models of ovarian cancer for novel drug discovery

Elizabeth Magnotti et al.

EXPERT OPINION ON DRUG DISCOVERY (2018)

Review Biochemistry & Molecular Biology

Fibroblasts in the Tumor Microenvironment: Shield or Spear?

Twana Alkasalias et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)

Review Cell Biology

Shedding light on the cell biology of extracellular vesicles

Guillaume van Niel et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Review Pharmacology & Pharmacy

Three-Dimensional in Vitro Cell Culture Models in Drug Discovery and Drug Repositioning

Sigrid A. Langhans

FRONTIERS IN PHARMACOLOGY (2018)

Review Oncology

The potential role of miRNAs and exosomes in chemotherapy in ovarian cancer

Mona Alharbi et al.

ENDOCRINE-RELATED CANCER (2018)

Article Oncology

Exosomal microRNAs as tumor markers in epithelial ovarian cancer

Chi Pan et al.

MOLECULAR ONCOLOGY (2018)

Article Multidisciplinary Sciences

Efficient scalable production of therapeutic microvesicles derived from human mesenchymal stem cells

Jae Min Cha et al.

SCIENTIFIC REPORTS (2018)

Article Biochemistry & Molecular Biology

Exosomal Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promotes Angiogenesis and Predicts Poor Prognosis in Epithelial Ovarian Cancer

Jun-Jun Qiu et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2018)

Article Chemistry, Multidisciplinary

Cancer-derived exosomes as a delivery platform of CRISPR/Cas9 confer cancer cell tropism-dependent targeting

Seung Min Kim et al.

JOURNAL OF CONTROLLED RELEASE (2017)

Article Medicine, General & Internal

Olaparib for Metastatic Breast Cancer in Patients with a Germline BRCA Mutation

Mark Robson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Oncology

Best practices in risk reducing bilateral salpingo-oophorectomy: the influence of surgical specialty

Dominique R. Malacarne et al.

WORLD JOURNAL OF SURGICAL ONCOLOGY (2017)

Article Multidisciplinary Sciences

Malignant extracellular vesicles carrying MMP1 mRNA facilitate peritoneal dissemination in ovarian cancer

Akira Yokoi et al.

NATURE COMMUNICATIONS (2017)

Article Oncology

High-grade serous ovarian cancer 3 years after bilateral salpingectomy: A case report

Emi Sato et al.

MOLECULAR AND CLINICAL ONCOLOGY (2017)

Article Chemistry, Multidisciplinary

Re-Engineering Extracellular Vesicles as Smart Nanoscale Therapeutics

James P. K. Armstrong et al.

ACS NANO (2017)

Review Oncology

Genetically-defined ovarian cancer mouse models

Patrice J. Morin et al.

JOURNAL OF PATHOLOGY (2016)

Review Biochemistry & Molecular Biology

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

Mercedes Tkach et al.

Article Biotechnology & Applied Microbiology

Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models

Mohamad Hadla et al.

NANOMEDICINE (2016)

Article Medicine, Research & Experimental

Recapitulating the Size and Cargo of Tumor Exosomes in a Tissue-Engineered Model

Aranzazu Villasante et al.

THERANOSTICS (2016)

Article Pharmacology & Pharmacy

The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease

Melanie L. Graham et al.

EUROPEAN JOURNAL OF PHARMACOLOGY (2015)

Article Multidisciplinary Sciences

Tumour exosome integrins determine organotropic metastasis

Ayuko Hoshino et al.

NATURE (2015)

Article Cell Biology

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

Bruno Costa-Silva et al.

NATURE CELL BIOLOGY (2015)

Article Biotechnology & Applied Microbiology

High LIN28A Expressing Ovarian Cancer Cells Secrete Exosomes That Induce Invasion and Migration in HEK293 Cells

Vanessa A. Enriquez et al.

BIOMED RESEARCH INTERNATIONAL (2015)

Article Biochemistry & Molecular Biology

Differentiation of tumour-promoting stromal myofibroblasts by cancer exosomes

J. P. Webber et al.

ONCOGENE (2015)

Review Cell Biology

Biological properties of extracellular vesicles and their physiological functions

Maria Yanez-Mo et al.

JOURNAL OF EXTRACELLULAR VESICLES (2015)

Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Oncology

Hematogenous Metastasis of Ovarian Cancer: Rethinking Mode of Spread

Sunila Pradeep et al.

CANCER CELL (2014)

Article Medicine, Research & Experimental

Ovarian cancer cell invasiveness is associated with discordant exosomal sequestration of Let-7 miRNA and miR-200

Miharu Kobayashi et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2014)

Article Biotechnology & Applied Microbiology

Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor

Hyungsoon Im et al.

NATURE BIOTECHNOLOGY (2014)

Article Multidisciplinary Sciences

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

Ting Wang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Quantitative and stoichiometric analysis of the microRNA content of exosomes

John R. Chevillet et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Review Pharmacology & Pharmacy

Exosomes as nucleic acid nanocarriers

Jasper G. van den Boorn et al.

ADVANCED DRUG DELIVERY REVIEWS (2013)

Article Cell Biology

In vitro three-dimensional modeling of fallopian tube secretory epithelial cells

Kate Lawrenson et al.

BMC CELL BIOLOGY (2013)

Article Biochemistry & Molecular Biology

Body Fluid Exosomes Promote Secretion of Inflammatory Cytokines in Monocytic Cells via Toll-like Receptor Signaling

Niko P. Bretz et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

Article Biochemical Research Methods

Two Distinct Populations of Exosomes Are Released from LIM1863 Colon Carcinoma Cell-derived Organoids

Bow J. Tauro et al.

MOLECULAR & CELLULAR PROTEOMICS (2013)

Article Medicine, Research & Experimental

A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro

Janet Myungjin Lee et al.

LABORATORY INVESTIGATION (2013)

Article Multidisciplinary Sciences

Evaluating cell lines as tumour models by comparison of genomic profiles

Silvia Domcke et al.

NATURE COMMUNICATIONS (2013)

Review Biotechnology & Applied Microbiology

Advances in the formation, use and understanding of multi-cellular spheroids

Toni-Marie Achilli et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2012)

Article Oncology

Low-grade serous carcinomas of the ovary contain very few point mutations

Sian Jones et al.

JOURNAL OF PATHOLOGY (2012)

Article Medicine, Research & Experimental

Performance of a multianalyte test as an aid for the diagnosis of ovarian cancer in symptomatic women

Dominic J. Autelitano et al.

JOURNAL OF TRANSLATIONAL MEDICINE (2012)

Article Biochemistry & Molecular Biology

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

Hector Peinado et al.

NATURE MEDICINE (2012)

Article Oncology

Modelling genetic and clinical heterogeneity in epithelial ovarian cancers

Kate Lawrenson et al.

CARCINOGENESIS (2011)

Article Oncology

Genomic Analysis Reveals the Molecular Heterogeneity of Ovarian Clear Cell Carcinomas

David S. P. Tan et al.

CLINICAL CANCER RESEARCH (2011)

Article Medicine, General & Internal

Effect of Screening on Ovarian Cancer Mortality The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial

Saundra S. Buys et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2011)

Review Oncology

Preclinical development of molecular-targeted agents for cancer

Alberto Ocana et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Editorial Material Oncology

High drug attrition rates-where are we going wrong?

Lisa Hutchinson et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2011)

Article Oncology

Molecular Characterization of 103 Ovarian Serous and Mucinous Tumors

Ildiko Vereczkey et al.

PATHOLOGY & ONCOLOGY RESEARCH (2011)

Article Pathology

The Origin and Pathogenesis of Epithelial Ovarian Cancer: A Proposed Unifying Theory

Robert J. Kurman et al.

AMERICAN JOURNAL OF SURGICAL PATHOLOGY (2010)

Article Oncology

Phase II biomarker trial of a multimarker diagnostic for ovarian cancer

Tracey Edgell et al.

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY (2010)

Article Oncology

Evaluation of midkine and anterior gradient 2 in a multimarker panel for the detection of ovarian cancer

Gregory E. Rice et al.

JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2010)

Editorial Material Obstetrics & Gynecology

Researchers find a new cancer gene and a possible link between ovarian cancer and endometriosis

[Anonymous]

WOMENS HEALTH (2010)

Article Medicine, General & Internal

ARID1A Mutations in Endometriosis-Associated Ovarian Carcinomas

Kimberly C. Wiegand et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Pathology

Frequent Activating Mutations of PIK3CA in Ovarian Clear Cell Carcinoma

Kuan-Ting Kuo et al.

AMERICAN JOURNAL OF PATHOLOGY (2009)

Review Oncology

Multicellular spheroids in ovarian cancer metastases: Biology and pathology

Kristy Shield et al.

GYNECOLOGIC ONCOLOGY (2009)

Review Reproductive Biology

Ovarian cancer mouse models: a summary of current models and their limitations

Miranda Y. Fong et al.

JOURNAL OF OVARIAN RESEARCH (2009)

Article Oncology

CD44v6 Dependence of Premetastatic Niche Preparation by Exosomes

Thorsten Jung et al.

NEOPLASIA (2009)

Review Obstetrics & Gynecology

Early detection and treatment of ovarian cancer: shifting from early stage to minimal volume of disease based on a new model of carcinogenesis

Robert J. Kurman et al.

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY (2008)

Review Biochemistry & Molecular Biology

Modeling tissue morphogenesis and cancer in 3D

Kenneth M. Yamada et al.

Review Oncology

Mechanisms of transcoelomic metastasis in ovarian cancer

David S. P. Tan et al.

LANCET ONCOLOGY (2006)

Article Obstetrics & Gynecology

Screening for ovarian cancer

Adam N. Rosenthal et al.

CLINICAL OBSTETRICS AND GYNECOLOGY (2006)

Review Cell Biology

Capturing complex 3D tissue physiology in vitro

LG Griffith et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Obstetrics & Gynecology

Clinical management of functional ovarian cysts: a prospective and randomized study

A MacKenna et al.

HUMAN REPRODUCTION (2000)