4.6 Article

Expression of Mismatch Repair Proteins in Merkel Cell Carcinoma

Related references

Note: Only part of the references are listed.
Review Oncology

Immunotherapy for Merkel cell carcinoma

Christina V. Angeles et al.

Summary: Merkel cell carcinoma (MCC) is an aggressive form of skin cancer that, while responsive to chemotherapy, often relapses and develops resistance, limiting the effectiveness of treatment. The management of advanced MCC has been significantly impacted by the introduction of checkpoint inhibitors. Ongoing research is focusing on immunotherapy for MCC in unresectable and metastatic cases, as well as exploring future immune-based strategies for this challenging cancer.

JOURNAL OF SURGICAL ONCOLOGY (2021)

Review Oncology

Management of Non-Colorectal Digestive Cancers with Microsatellite Instability

Mojun Zhu et al.

Summary: Microsatellite instability (MSI) is a genetic predisposition to DNA damage, detectable through sequencing or immunohistochemistry, and associated with a high neoantigen load and favorable response to immune checkpoint inhibitors (ICIs). In gastrointestinal cancers, MSI serves as a predictive biomarker for ICIs with varying clinical utility depending on tumor type, potentially explained by the complex tumor microenvironment. This review explores the predictive and prognostic value of MSI in non-colorectal cancers of the digestive system and strategies to overcome immunotherapy resistance.

CANCERS (2021)

Article Dermatology

Patched 1 expression in Merkel cell carcinoma

Thilo Gambichler et al.

Summary: The study investigated the expression of Hedgehog signaling molecules in Merkel cell carcinoma, revealing variability in expression and its correlation with the clinical course of the patients. The findings suggest that factors other than methylation may play a role in the differential expression of PTCH1 in Merkel cell carcinoma cell lines, with PTCH1 being upregulated by GLI as a classical Hedgehog target gene.

JOURNAL OF DERMATOLOGY (2021)

Review Oncology

Microsatellite instability: a review of what the oncologist should know

Kai Li et al.

CANCER CELL INTERNATIONAL (2020)

Editorial Material Dermatology

S2k guidelines for Merkel cell carcinoma (MCC, neuroendocrine carcinoma of the skin) - update 2018

Juergen C. Becker et al.

JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2019)

Review Medicine, Research & Experimental

Existing and Emerging Biomarkers for Immune Checkpoint Immunotherapy in Solid Tumors

Sanjeevani Arora et al.

ADVANCES IN THERAPY (2019)

Review Oncology

Immune Checkpoint Inhibitors in the Treatment of Patients with Neuroendocrine Neoplasia

Matthias M. Weber et al.

ONCOLOGY RESEARCH AND TREATMENT (2018)

Article Medicine, General & Internal

Merkel cell carcinoma

Juergen C. Becker et al.

NATURE REVIEWS DISEASE PRIMERS (2017)

Review Oncology

Microsatellite instability in melanoma: a comprehensive review

Ondrej Kubecek et al.

MELANOMA RESEARCH (2016)

Review Oncology

Deficient mismatch repair: Read all about it

Susan Richman

INTERNATIONAL JOURNAL OF ONCOLOGY (2015)

Article Pathology

High Expression of the Mismatch Repair Protein MSH6 Is Associated With Poor Patient Survival in Melanoma

Ester Alvino et al.

AMERICAN JOURNAL OF CLINICAL PATHOLOGY (2014)

Review Oncology

Merkel cell carcinoma: recent insights and new treatment options

David Schrama et al.

CURRENT OPINION IN ONCOLOGY (2012)

Letter Dermatology

Absence of Mismatch Repair Deficiency-Related Microsatellite Instability in Non-Melanoma Skin Cancer

Miriam Reuschenbach et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2012)

Article Dermatology

No evidence for a causal role of Merkel cell polyomavirus in keratoacanthoma

Ulrike Wieland et al.

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY (2012)

Article Oncology

Clinical Factors Associated With Merkel Cell Polyomavirus Infection in Merkel Cell Carcinoma

Harri Sihto et al.

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2009)

Article Immunology

Merkel Cell Polyomavirus DNA in Persons without Merkel Cell Carcinoma

Ulrike Wieland et al.

EMERGING INFECTIOUS DISEASES (2009)

Article Pathology

Mutations of microsatellite instability target genes in sporadic basal cell carcinomas

Angelica A. Saetta et al.

PATHOLOGY RESEARCH AND PRACTICE (2007)