4.6 Article

3D Model of the Early Melanoma Microenvironment Captures Macrophage Transition into a Tumor-Promoting Phenotype

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Stromal Cells Present in the Melanoma Niche Affect Tumor Invasiveness and Its Resistance to Therapy

Justyna Mazurkiewicz et al.

Summary: Malignant melanoma is a highly metastatic type of cancer that often arises from long-term UV exposure. Despite advancements in targeted therapies, patients' response is often limited due to drug resistance. The tumor microenvironment, including cancer-associated cells, plays a crucial role in melanoma progression and drug resistance.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Cell Biology

Engineered ECM models: Opportunities to advance understanding of tumor heterogeneity

Adrian A. Shimpi et al.

Summary: Intratumoral heterogeneity is a negative prognostic factor for cancer, often caused by microenvironment-driven genetic mutations and alterations in cancer stem-like cells. Understanding how aberrant extracellular matrix (ECM) remodeling affects the phenotypic diversity of tumor cells is still limited, but biomaterials and engineering approaches offer opportunities to study this relationship in vitro and in vivo. Further research is needed to explore the spatiotemporal dynamics through which cancer-associated ECM remodeling influences intratumoral heterogeneity and the cancer stem-like cell phenotype.

CURRENT OPINION IN CELL BIOLOGY (2021)

Article Multidisciplinary Sciences

Co-stimulation with opposing macrophage polarization cues leads to orthogonal secretion programs in individual cells

Andres R. Munoz-Rojas et al.

Summary: The study using single-cell RNA sequencing to explore co-stimulated macrophages reveals cell-to-cell heterogeneity in transcription and mutually exclusive expression of specific genes, supporting the maintenance of specialized functions for at least 48 hours. This suggests that increasing functional diversity in the macrophage population is an effective strategy to respond to conflicting environmental cues.

NATURE COMMUNICATIONS (2021)

Review Immunology

Immunotherapy Goes Local: The Central Role of Lymph Nodes in Driving Tumor Infiltration and Efficacy

Kim M. van Pul et al.

Summary: Immune checkpoint blockade (ICB) has revolutionized oncology treatment, but resistance related to T cell deficiency and the importance of tumor-draining lymph nodes (TDLN) in overcoming this resistance have been overlooked. Targeting TDLN through therapeutic approaches involving DC activation may enhance ICB efficacy.

FRONTIERS IN IMMUNOLOGY (2021)

Review Oncology

Therapeutic Targeting of the Tumor Microenvironment

Leire Bejarano et al.

Summary: This review provides a comprehensive analysis of the current therapies targeting the TME, combining a discussion of the underlying basic biology with clinical evaluation of different therapeutic approaches, and highlighting the challenges and future perspectives.

CANCER DISCOVERY (2021)

Article Oncology

Fibroblast MMP14-Dependent Collagen Processing Is Necessary for Melanoma Growth

Elke Pach et al.

Summary: Research suggests that specific inhibition of MMP14 can slow down melanoma growth, with collagen accumulation in the matrix environment helping to reduce tumor cell proliferation and vessel density.

CANCERS (2021)

Article Engineering, Biomedical

High-throughput microfluidic 3D biomimetic model enabling quantitative description of the human breast tumor microenvironment

Ilana Berger Fridman et al.

Summary: Cancer progression is driven by changes in tumor cells and surrounding stroma. The study demonstrates a high throughput microfluidic system for generating dynamic tumor-stroma scaffolds that mimic in vivo TME, with Alg/Alg-S promoting in vivo-like responses and potential therapeutic targets for breast cancer treatment. Formation of large tumor-derived vesicles in Alg/Alg-S scaffolds suggests a mechanism for tumor survival.

ACTA BIOMATERIALIA (2021)

Article Oncology

A Phase I Study of APX005M and Cabiralizumab with or without Nivolumab in Patients with Melanoma, Kidney Cancer, or Non-Small Cell Lung Cancer Resistant to Anti-PD-1/PD-L1

Sarah A. Weiss et al.

Summary: This first in-human study of patients with anti-PD-1/PD-Li-resistant tumors treated with dual macrophage polarizing therapy, with or without nivolumab, demonstrated safety and pharmacodynamic activity. Further optimization of the dosing frequency and sequence of this combination is warranted.

CLINICAL CANCER RESEARCH (2021)

Article Multidisciplinary Sciences

Tissue-resident macrophages provide a pro-tumorigenic niche to early NSCLC cells

Maria Casanova-Acebes et al.

Summary: Macrophages play a crucial role in shaping the tumor microenvironment and tumor immunity, with tissue-resident macrophages identified as key contributors to early lung cancer progression. Targeting tissue-resident macrophages may offer new possibilities for prevention and treatment of early lung cancer lesions.

NATURE (2021)

Article Multidisciplinary Sciences

Topical arginase inhibition decreases growth of cutaneous squamous cell carcinoma

Amit Mittal et al.

Summary: This study investigates the therapeutic potential of transcutaneous arginase inhibition in cSCC, requiring a competent immune microenvironment for tumor growth inhibition using this method. The results support further examination of transcutaneous arginase inhibition as a therapeutic modality for cSCC, showing synergistic co-inhibition of tumor growth.

SCIENTIFIC REPORTS (2021)

Article Cell Biology

Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses

Kai Yu et al.

Summary: This study identifies a mechanism of myeloid cell-mediated immune suppression by revealing the role of nitric oxide production and protein nitrosylation in cell adhesion. This provides important insights for future therapeutic applications.

CELL REPORTS (2021)

Article Biology

Tumor stiffening reversion through collagen crosslinking inhibition improves T cell migration and anti-PD-1 treatment

Alba Nicolas-Boluda et al.

Summary: The study found that tumor stiffness is strongly correlated with tumor growth and ECM crosslinking, but negatively correlated with T cell migration. Interfering with collagen stabilization can reduce ECM content and tumor stiffness, improving T cell migration and the efficacy of anti-PD-1 blockade.

ELIFE (2021)

Article Multidisciplinary Sciences

Lactate and IL6 define separable paths of inflammatory metabolic adaptation

Stefanie Dichtl et al.

Summary: Lactate, a product of Warburg-type metabolism in inflammatory macrophages, has been shown to modify histones and promote gene expression related to tissue repair. The presence of IL6 and Arg1 is correlated with Kla, suggesting a metabolic rewiring in macrophages under inflammatory stress.

SCIENCE ADVANCES (2021)

Review Oncology

In Vitro 3D Cultures to Model the Tumor Microenvironment

Fabrizio Fontana et al.

Summary: This review highlights the significance of tumor stroma in cancer biology and treatment research. It emphasizes the importance and advantages of 3D cell culture models. Understanding the interactions between tumor cells and stroma is crucial for disease initiation and progression, as the tumor microenvironment plays a key role in cancer growth, metastasis, and drug resistance.

CANCERS (2021)

Review Immunology

Unfolding innate mechanisms in the cancer microenvironment: The emerging role of the mesenchyme

Vasiliki Koliaraki et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2020)

Article Biochemistry & Molecular Biology

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Lei Zhang et al.

Review Biochemistry & Molecular Biology

Fractalkine/CX3CL1 in Neoplastic Processes

Jan Korbecki et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Multidisciplinary Sciences

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

S. Di Blasio et al.

NATURE COMMUNICATIONS (2020)

Review Immunology

The Tumor Microenvironment: A Milieu Hindering and Obstructing Antitumor Immune Responses

Alireza Labani-Motlagh et al.

FRONTIERS IN IMMUNOLOGY (2020)

Article Multidisciplinary Sciences

A conserved dendritic-cell regulatory program limits antitumour immunity

Barbara Maier et al.

NATURE (2020)

Review Oncology

Biomechanical Contributions to Macrophage Activation in the Tumor Microenvironment

Erica J. Hoffmann et al.

FRONTIERS IN ONCOLOGY (2020)

Article Immunology

Collagen Density Modulates the Immunosuppressive Functions of Macrophages

Anne Mette H. Larsen et al.

JOURNAL OF IMMUNOLOGY (2020)

Article Oncology

Pathology of spontaneous and immunotherapy-induced tumor regression in a murine model of melanoma

Kim R. M. Blenman et al.

PIGMENT CELL & MELANOMA RESEARCH (2019)

Article Biochemical Research Methods

Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices

Andrea Malandrino et al.

PLOS COMPUTATIONAL BIOLOGY (2019)

Review Immunology

Re-education of macrophages as a therapeutic strategy in cancer

Joanna Kowal et al.

IMMUNOTHERAPY (2019)

Article Multidisciplinary Sciences

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

Pardis Pakshir et al.

NATURE COMMUNICATIONS (2019)

Article Pathology

Diversity, Mechanisms, and Significance of Macrophage Plasticity

Massimo Locati et al.

Annual Review of Pathology-Mechanisms of Disease (2019)

Article Biotechnology & Applied Microbiology

Visualizing structure and transitions in high-dimensional biological data

Kevin R. Moon et al.

NATURE BIOTECHNOLOGY (2019)

Article Engineering, Biomedical

Matrix crosslinking enhances macrophage adhesion, migration, and inflammatory activation

Jessica Y. Hsieh et al.

APL BIOENGINEERING (2019)

Article Oncology

Ex Vivo Profiling of PD-1 Blockade Using Organotypic Tumor Spheroids

Russell W. Jenkins et al.

CANCER DISCOVERY (2018)

Article Biochemistry & Molecular Biology

Circuit Design Features of a Stable Two-Cell System

Xu Zhou et al.

Article Immunology

Myeloid-targeted immunotherapies act in synergy to induce inflammation and antitumor immunity

Curtis J. Perry et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2018)

Article Multidisciplinary Sciences

Cancer-associated fibroblasts induce antigen-specific deletion of CD8+ T Cells to protect tumour cells

Matthew A. Lakins et al.

NATURE COMMUNICATIONS (2018)

Review Immunology

Chemokine-Induced Macrophage Polarization in Inflammatory Conditions

Pieter Ruytinx et al.

FRONTIERS IN IMMUNOLOGY (2018)

Article Chemistry, Physical

Spatial confinement downsizes the inflammatory response of macrophages

Nikhil Jain et al.

NATURE MATERIALS (2018)

Article Medicine, Research & Experimental

Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages

Sean P. Arlauckas et al.

THERANOSTICS (2018)

Article Cell Biology

In vivo imaging reveals a tumor-associated macrophage-mediated resistance pathway in anti-PD-1 therapy

Sean P. Arlauckas et al.

SCIENCE TRANSLATIONAL MEDICINE (2017)

Article Immunology

Tumor macrophages are pivotal constructors of tumor collagenous matrix

Ran Afik et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2016)

Article Oncology

The YUMM lines: a series of congenic mouse melanoma cell lines with defined genetic alterations

Katrina Meeth et al.

PIGMENT CELL & MELANOMA RESEARCH (2016)

Article Multidisciplinary Sciences

Call Off the Dog(ma): M1/M2 Polarization Is Concurrent following Traumatic Brain Injury

Josh M. Morganti et al.

PLOS ONE (2016)

Article Nanoscience & Nanotechnology

Micro- and Nanopatterned Topographical Cues for Regulating Macrophage Cell Shape and Phenotype

Thuy U. Luu et al.

ACS APPLIED MATERIALS & INTERFACES (2015)

Review Multidisciplinary Sciences

The future of immune checkpoint therapy

Padmanee Sharma et al.

SCIENCE (2015)

Article Multidisciplinary Sciences

PD-1 blockade induces responses by inhibiting adaptive immune resistance

Paul C. Tumeh et al.

NATURE (2014)

Article Immunology

Myeloid colony-stimulating factors as regulators of macrophage polarization

Thomas A. Hamilton et al.

FRONTIERS IN IMMUNOLOGY (2014)

Article Multidisciplinary Sciences

Modulation of macrophage phenotype by cell shape

Frances Y. McWhorter et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Multidisciplinary Sciences

Bone Marrow-derived Macrophage Production

Virginie Trouplin et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2013)

Review Oncology

Activation of fibroblasts in cancer stroma

Kati Rasanen et al.

EXPERIMENTAL CELL RESEARCH (2010)