4.6 Review

Hampering Stromal Cells in the Tumor Microenvironment as a Therapeutic Strategy to Destem Cancer Stem Cells

Related references

Note: Only part of the references are listed.
Article Oncology

Regulatory T cells promote glioma cell stemness through TGF-β-NF-κB-IL6-STAT3 signaling

Shasha Liu et al.

Summary: The intense infiltration of regulatory T cells (Tregs) facilitates the qualities of glioma stem cells (GSCs) through TGF-beta secretion and NF-κB-IL6-STAT3 signaling pathway, leading to increased cancer stemness and tumorigenic potential. Blocking the IL6 receptor can mitigate the promotion effect of Tregs on glioma growth, and the expression levels of CD133, IL6, and TGF-beta could serve as prognosis markers for glioma patients.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

Article Gastroenterology & Hepatology

Cancer-Associated Fibroblast-Mediated Cellular Crosstalk Supports Hepatocellular Carcinoma Progression

Mengjia Song et al.

Summary: This study revealed a cytokine-mediated cellular crosstalk and clinical network involving the CLCF1-CXCL6/TGF-beta axis, which regulates the positive feedback loop among CAFs, tumor stemness, and TANs, HCC progression, and patient prognosis. The up-regulation of the CLCF1-CXCL6/TGF-beta axis in clinical samples showed a correlation with increased cancer stem cells, N2-polarized TANs, tumor stage, and poor prognosis. This suggests the CLCF1 cascade could be a potential prognostic biomarker and targeting CLCF1/ ciliary neurotrophic factor receptor or ERK1/2 signaling could provide an effective therapeutic target for patients with HCC.

HEPATOLOGY (2021)

Review Medicine, Research & Experimental

Targeting transforming growth factor-β signaling for enhanced cancer chemotherapy

Jitang Chen et al.

Summary: Targeting TGF beta signaling for cancer therapy presents challenges and opportunities, as inhibitors can enhance chemotherapy efficacy but must also consider the dual role of TGF beta in normal tissues and tumors to avoid unwanted side effects.

THERANOSTICS (2021)

Meeting Abstract Biochemistry & Molecular Biology

The Role of Cancer Associated Fibroblasts in Maintaining Cancer Stem Cells

Shantae Lewis et al.

FASEB JOURNAL (2020)

Review Medicine, General & Internal

CAR-NK cells: A promising cellular immunotherapy for cancer

Guozhu Xie et al.

EBIOMEDICINE (2020)

Article Oncology

A framework for advancing our understanding of cancer-associated fibroblasts

Erik Sahai et al.

NATURE REVIEWS CANCER (2020)

Article Multidisciplinary Sciences

Cancer stemness, intratumoral heterogeneity, and immune response across cancers

Alex Miranda et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Medicine, General & Internal

Snail1-dependent cancer-associated fibroblasts induce epithelial-mesenchymal transition in lung cancer cells via exosomes

J. You et al.

QJM-AN INTERNATIONAL JOURNAL OF MEDICINE (2019)

Review Immunology

Targeting Tumor-Associated Macrophages in Cancer

Paulina Pathria et al.

TRENDS IN IMMUNOLOGY (2019)

Article Multidisciplinary Sciences

Endothelial cells promote 3D invasion of GBM by IL-8-dependent induction of cancer stem cell properties

Michael G. McCoy et al.

SCIENTIFIC REPORTS (2019)

Review Cell & Tissue Engineering

Targeting Cancer Stemness in the Clinic: From Hype to Hope

Caner Saygin et al.

CELL STEM CELL (2019)

Review Cell Biology

Cancer stem cells (CSCs) in cancer progression and therapy

Masoud Najafi et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Medicine, Research & Experimental

Cancer-associated fibroblasts regulate endothelial adhesion protein LPP to promote ovarian cancer chemoresistance

Cecilia S. Leung et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Medicine, Research & Experimental

Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

Veronica Huber et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Article Biochemistry & Molecular Biology

Adipocyte microenvironment promotes Bclxl expression and confers chemoresistance in ovarian cancer cells

Carlos Cardenas et al.

APOPTOSIS (2017)

Review Biotechnology & Applied Microbiology

Targeting Cancer Stem Cells with Natural Killer Cell Immunotherapy

Jesus I. Luna et al.

EXPERT OPINION ON BIOLOGICAL THERAPY (2017)

Article Cell Biology

Targeting TGF-β Signaling for Therapeutic Gain

Rosemary J. Akhurst

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2017)

Article Oncology

Pirfenidone normalizes the tumor microenvironment to improve chemotherapy

Christiana Polydorou et al.

ONCOTARGET (2017)

Review Oncology

The biology and function of fibroblasts in cancer

Raghu Kalluri

NATURE REVIEWS CANCER (2016)

Review Immunology

FOXP3+ regulatory T cells and their functional regulation

Zhiyuan Li et al.

CELLULAR & MOLECULAR IMMUNOLOGY (2015)

Article Immunology

NK Cells Preferentially Target Tumor Cells with a Cancer Stem Cell Phenotype

Erik Ames et al.

JOURNAL OF IMMUNOLOGY (2015)

Review Cell Biology

Distinct Functions of Neutrophil in Cancer and Its Regulation

Zvi Granot et al.

MEDIATORS OF INFLAMMATION (2015)

Article Biochemistry & Molecular Biology

Endothelial cells induce cancer stem cell features in differentiated glioblastoma cells via bFGF

Evelyn Fessler et al.

MOLECULAR CANCER (2015)

Article Multidisciplinary Sciences

Neutrophils support lung colonization of metastasis-initiating breast cancer cells

Stefanie K. Wculek et al.

NATURE (2015)

Article Pathology

Cancers with Higher Density of Tumor-Associated Macrophages Were Associated with Poor Survival Rates

Kyong Yeun Jung et al.

JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE (2015)

Review Cell Biology

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Marina Colombo et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30 (2014)

Article Oncology

CXCR2-mediated tumor-associated neutrophil recruitment is regulated by IFN-β

J. Jablonska et al.

INTERNATIONAL JOURNAL OF CANCER (2014)

Article Medicine, Research & Experimental

NOTCH-induced aldehyde dehydrogenase 1A1 deacetylation promotes breast cancer stem cells

Di Zhao et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Multidisciplinary Sciences

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

Wan-Jiun Chen et al.

NATURE COMMUNICATIONS (2014)

Review Biochemistry & Molecular Biology

Recruitment of monocytes/macrophages in different tumor microenvironments

Heon-Woo Lee et al.

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2013)

Article Immunology

Tumor associated macrophages and neutrophils in cancer

Maria Rosaria Galdiero et al.

IMMUNOBIOLOGY (2013)

Article Multidisciplinary Sciences

Wnt Pathway Activity in Breast Cancer Sub-Types and Stem-Like Cells

Rebecca Lamb et al.

PLOS ONE (2013)

Article Multidisciplinary Sciences

Targeting CXCL12 from FAP-expressing carcinomaassociated fibroblasts synergizes with anti-PD-L1 immunotherapy in pancreatic cancer

Christine Feig et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Oncology

Regulatory T cells increase in breast cancer and in stage IV breast cancer

Zhi-kuan Wang et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2012)

Review Biochemistry & Molecular Biology

The Behavior of Matrix Metalloproteinases and Their Inhibitors in Colorectal Cancer

Laszlo Herszenyi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2012)

Article Multidisciplinary Sciences

Pluripotency factor-mediated expression of the leptin receptor (OB-R) links obesity to oncogenesis through tumor-initiating stem cells

Douglas Edmund Feldman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)

Review Pharmacology & Pharmacy

Classification, Functions, and Clinical Relevance of Extracellular Vesicles

Edwin van der Pol et al.

PHARMACOLOGICAL REVIEWS (2012)

Review Immunology

Coordinated regulation of myeloid cells by tumours

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2012)

Review Medicine, Research & Experimental

Breast cancer stem cells, cytokine networks, and the tumor microenvironment

Hasan Korkaya et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Medicine, Research & Experimental

The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24- stem cell-like breast cancer cells in human tumors

Lauren L. C. Marotta et al.

JOURNAL OF CLINICAL INVESTIGATION (2011)

Article Cell Biology

Foxp3(+)IL-17(+) T cells promote development of cancer-initiating cells in colorectal cancer

Shaobo Yang et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2011)

Article Multidisciplinary Sciences

Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and Treg cells

Andrea Facciabene et al.

NATURE (2011)

Review Medicine, Research & Experimental

Biological Mechanisms Linking Obesity and Cancer Risk: New Perspectives

Darren L. Roberts et al.

ANNUAL REVIEW OF MEDICINE (2010)

Review Biochemistry & Molecular Biology

Macrophage Diversity Enhances Tumor Progression and Metastasis

Bin-Zhi Qian et al.

Article Multidisciplinary Sciences

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

Lucia Ricci-Vitiani et al.

NATURE (2010)

Article Immunology

Natural killer cells kill human melanoma cells with characteristics of cancer stem cells

Gabriella Pietra et al.

INTERNATIONAL IMMUNOLOGY (2009)

Article Immunology

NK Cells Recognize and Kill Human Glioblastoma Cells with Stem Cell-Like Properties

Roberta Castriconi et al.

JOURNAL OF IMMUNOLOGY (2009)

Review Immunology

Myeloid-derived suppressor cells as regulators of the immune system

Dmitry I. Gabrilovich et al.

NATURE REVIEWS IMMUNOLOGY (2009)

Article Gastroenterology & Hepatology

Identification and characterization of tumorigenic liver cancer stem/progenitor cells

Stephanie Ma et al.

GASTROENTEROLOGY (2007)

Article Multidisciplinary Sciences

TGFβ promotes conversion of CD16+ peripheral blood NK cells into CD16- NK cells with similarities to decidual NK cells

Derin B. Keskin et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

Article Multidisciplinary Sciences

A human colon cancer cell capable of initiating tumour growth in immunodeficient mice

Catherine A. O'Brien et al.

NATURE (2007)

Article Oncology

A perivascular niche for brain tumor stem cells

Christopher Calabrese et al.

CANCER CELL (2007)

Article Biochemistry & Molecular Biology

Decidual NK cells regulate key developmental processes at the human fetal-maternal interface

Jacob Hanna et al.

NATURE MEDICINE (2006)

Article Neurosciences

Pigment epithelium-derived factor is a niche signal for neural stem cell renewal

C Ramírez-Castillejo et al.

NATURE NEUROSCIENCE (2006)

Article Oncology

Prospective identification of tumorigenic prostate cancer stem cells

AT Collins et al.

CANCER RESEARCH (2005)

Review Immunology

Regulation of immune responses by L- arginine metabolism

V Bronte et al.

NATURE REVIEWS IMMUNOLOGY (2005)

Article Multidisciplinary Sciences

Prospective identification of tumorigenic breast cancer cells

M Al-Hajj et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)