Journal
CANCERS
Volume 13, Issue 17, Pages -Publisher
MDPI
DOI: 10.3390/cancers13174256
Keywords
anaplastic large cell lymphoma; oncogenesis; cytokine; signaling pathways
Categories
Funding
- Ligue contre le Cancer
- Canceropole Grand Sud-Ouest
- Societe Francaise de Dermatologie
- Aesthetic Surgery Education and Research Foundation
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ALCL is a tumor of activated T cells and possibly innate lymphoid cells with several subtypes according to clinical presentation and genetic lesions. The review focuses on the biology of the main ALCL subtypes and the potential for targeted therapies based on the identification of signaling pathways and ALCL-derived cytokines.
Simple Summary This review summarizes the main features of anaplastic large cell lymphoma (ALCL) subtypes focusing on activated biological pathways that may have clinical significance for diagnosis, prognosis and personalized therapy. ALCL is a tumor of activated T cells and possibly innate lymphoid cells with several subtypes according to clinical presentation and genetic lesions. On one hand, the expression of transcription factors and cytokine receptors triggers signaling pathways. On the other hand, ALCL tumor cells also produce many proteins including chemokines, cytokines and growth factors that affect patient symptoms. Examples are accumulation of granulocytes stimulated by IL-8, IL-17, IL-9 and IL-13; epidermal hyperplasia and psoriasis-like skin lesions due to IL-22; and fever and weight loss in response to IL-6 and IFN-gamma. In this review, we focus on the biology of the main ALCL subtypes as the identification of signaling pathways and ALCL-derived cytokines offers opportunities for targeted therapies.
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