Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/jcm10163757
Keywords
cytokines; immune checkpoints; immune disorders; lymphocytes; pulmonary arterial hypertension
Categories
Funding
- Medical University of Lublin [DS376, DS460]
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Pulmonary arterial hypertension (PAH) is a relatively rare but increasingly incident disease, posing a significant diagnostic and therapeutic challenge due to its severe course and low patient survival rate. Research indicates that abnormalities within the immune system play a crucial role in the development of PAH, affecting the progression of the disease significantly. This review highlights the importance of understanding the immune system's role in PAH development to improve diagnosis and targeted immunotherapy.
Pulmonary arterial hypertension (PAH) is a relatively rare disease, but, today, its incidence tends to increase. The severe course of the disease and poor patient survival rate make PAH a major diagnostic and therapeutic challenge. For this reason, a thorough understanding of the pathogenesis of the disease is essential to facilitate the development of more effective therapeutic targets. Research shows that the development of PAH is characterized by a number of abnormalities within the immune system that greatly affect the progression of the disease. In this review, we present key data on the regulated function of immune cells, released cytokines and immunoregulatory molecules in the development of PAH, to help improve diagnosis and targeted immunotherapy.
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