Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 16, Pages -Publisher
MDPI
DOI: 10.3390/jcm10163606
Keywords
acute cholangitis; disseminated intravascular coagulation; endoscopic biliary drainage; endoscopic retrograde cholangiopancreatography; clinical outcome
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Early endoscopic transpapillary biliary drainage is effective and safe for patients with acute cholangitis associated with disseminated intravascular coagulation (DIC). Both endoscopic biliary stenting and endoscopic nasobiliary drainage are effective in improving clinical outcomes in these patients.
Acute cholangitis (AC) is often associated with disseminated intravascular coagulation (DIC), and endoscopic transpapillary biliary drainage (EBD) under endoscopic retrograde cholangiopancreatography (ERCP) is a treatment of choice. However, no evidence exists on the outcomes of EBD for AC associated with DIC. Therefore, we retrospectively evaluated the treatment outcomes of early EBD and compared endoscopic biliary stenting (EBS) and endoscopic nasobiliary drainage (ENBD). We included 62 patients who received early EBD (EBS: 30, ENBD: 32) for AC, associated with DIC. The rates of clinical success for AC and DIC resolution at 7 days after EBD were 90.3% and 88.7%, respectively. Mean hospitalization period was 31.7 days, and in-hospital mortality rate was 4.8%. ERCP-related adverse events developed in 3.2% of patients (bleeding in two patients). Comparison between EBS and ENBD groups showed that the ENBD group included patients with more severe cholangitis, and acute physiology and chronic health evaluation II score, systemic inflammatory response syndrome score, and serum bilirubin level were significantly higher in this group. However, no significant difference was observed in clinical outcomes between the two groups; both EBS and ENBD were effective. In conclusion, early EBD is effective and safe for patients with AC associated with DIC.
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