Journal
JOURNAL OF CLINICAL MEDICINE
Volume 10, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/jcm10132860
Keywords
platelet activation; sCLEC-2; DIC; poor outcome
Categories
Funding
- Ministry of Health [H30-015]
- Labour andWelfare of Japan
- LSI Medience [O-0057]
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The plasma levels of sCLEC-2 and D-dimer are significantly higher in patients with DIC and Pre-DIC, serving as markers for these conditions and as prognostic indicators in critically ill patients.
Disseminated intravascular coagulation (DIC) is induced by excess activation coagulation, and activated platelets are also involved in pathogenesis. Therefore, plasma levels of soluble C-type lectin-like receptor 2 (sCLEC-2), a new marker for platelet activation, can be expected as a marker of DIC in critically ill patients. Plasma levels of sCLEC-2 and D-dimer were measured using the STACIA system. Plasma sCLEC-2 and D-dimer levels were significantly higher in patients with underlying diseases of DIC than in those with unidentified clinical syndrome (UCS). Plasma sCLEC-2 levels were significantly higher in the patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. Similarly, plasma D-dimer levels were also significantly higher in patients with DIC and Pre-DIC than in those without DIC or Pre-DIC. The plasma sCLEC-2 levels in all patients and those with a DIC score <= 4 were significantly higher in non-survivors than survivors. The plasma D-dimer levels in all patients, those with a DIC score >= 5 and those with a DIC score <= 4, were significantly higher in non-survivors than in survivors. The plasma sCLEC-2 is expected as a marker for DIC/Pre-DIC as well as the prognostic marker in critically ill patients.
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